Recombinant full-length human UBE2J1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U225-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
U225-30G-20 | 20 ug | $215 | |
U225-30G-50 | 50 ug | $435 | |
U225-30G-BULK | BULK | Contact Us |
Overview:
UBE2J1 is a member of the E2 ubiquitin-conjugating enzyme family which is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. UBE2J1 is play an important role in the homeostatic regulation of MHC class I assembly and expression (1). HRD1 and UBE2J1 associate in a complex together with non-β2m bound MHC class I heavy chains, Derlin 1, and p97 and discriminate misfolded MHC class I from conformational MHC I-β2m-peptide heterotrimers.
Gene Aliases:
CGI-76; HSPC153; HSPC205; HSU93243; NCUBE-1; NCUBE1; UBC6; Ubc6p
Genbank Number:
References:
1. Burr ML. et. al: HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci U S A. 2011 Feb 1.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~70 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Neurobiology
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