SignalChem places a great deal of emphasis on delivering high quality research related products and services to enable your discovery efforts. Should you have a general inquiry about our products or services, we would be pleased to assist you.
SignalChem understands the importance of hassle free deliveries. Hence, we place the utmost importance on delivering your products in good condition and on time.
Quickly find out if we have already addressed your query; click on a question to drop down to the answer.
(Negative)-Regulation of Cyclin-Dependent Kinases
The cell cycle is controlled by a series of checkpoints which when bypassed, enable the cell to proceed with division and replication. Cyclin-dependent kinases (CDKs) are the primary regulators of the cell cycle. CDKs are small with much of the peptide sequence representing its protein kinase domain; therefore, CDKs rely on interactions with cyclin regulatory subunits for enzyme activation and target specificity. Cyclins achieve temporal control of CDK function via fluctuations in their synthesis and degradation.
play pivotal roles in the ubiquitin-proteasome cellular pathway. Due to their involvement in multiple key cell signaling processes
encompassing diseases such as cancer and neurodegeneration, these enzymes have evolved to be important new therapeutic targets.