Members of the kinase superfamily are key regulators of pivotal cell signaling pathways. Genetic alterations in protein kinases compromise their biological functions resulting in deregulated cellular pathways such as apoptosis, cell cycle regulation, proliferation, angiogenesis, differentiation, cellular metabolism. Mutations in kinase-encoding genes have been observed in many pathological conditions, ranging from cancer, inflammatory disorders, cardiovascular diseases to neurodegeneration (1). Furthermore, mutations of certain kinases have been linked to acquired drug resistance. As a result, mutant kinases quickly established themselves as important drug targets and have been the focus of drug discovery and development efforts (2).
In an effort to support the advancement of next generation of kinase-targeted therapeutic programs, SignalChem has developed and manufactured over 250 clinically relevant active kinase mutants, representing the most comprehensive list of this class of proteins in the industry.
References:
1. Kumar R et al., CancerDR: cancer drug resistance database. Sci Rep. 2013;3:1445. doi: 10.1038/srep01445.
2. Torkamani, A., Verkhivker, G., & Schork, N. J. (2009). Cancer driver mutations in protein kinase genes. Cancer Letters, 281(2), 117–127.
http://doi.org/10.1016/j.canlet.2008.11.008
Name | Catalog Number | Species | Tag | Expression System | Sequence | Genbank Number |
ABL1 (E255K), Active | A03-12BG | Human | GST | Sf9 insect cells using baculovirus | 27-end (E255K) | NM_005157 |
ABL1 (E255V), Active | A03-12HH | Human | HIS | Sf9 insect cells using baculovirus | 27-end (E255V) | NM_005157 |
ABL1 (F317I), Active | A03-12JG | Human | GST | Sf9 insect cells using baculovirus | 27-end (F317I) | NM_005157 |
ABL1 (F317L), Active | A03-12IG | Human | GST | Sf9 insect cells using baculovirus | 27-end (F317L) | NM_005157 |
ABL1 (H396P), Active | A03-12LG | Human | GST | Sf9 insect cells using baculovirus | 27-end (H396P) | NM_005157 |
ABL1 (K290R) Protein | A03-16NG | Human | HIS | Sf9 insect cells using baculovirus | 27-end (K290R) | NM_005157 |
ABL1 (M351T), Active | A03-12KG | Human | GST | Sf9 insect cells using baculovirus | 27-end (M351T) | NM_005157 |
ABL1 (Q252H), Active | A03-12FG | Human | GST | Sf9 insect cells using baculovirus | 27-end (Q252H) | NM_005157 |
ABL1 (T315I), Active | A03-12DG | Human | GST | Sf9 insect cells using baculovirus | 27-end (T315I) | NM_005157 |
ABL1 (V299L), Active | A03-12MG | Human | GST | Sf9 insect cells using baculovirus | 27-end (V299L) | NM_005157 |
ABL1 (Y245F Y412F), Active | A03-12QH | Human | HIS | Sf9 insect cells using baculovirus | 27-end (Y245F Y412F) | NM_005157 |
ABL1 (Y245F), Active | A03-12PH | Human | HIS | Sf9 insect cells using baculovirus | 27-end (Y245F) | NM_005157 |
ABL1 (Y253F), Active | A03-12EG | Human | GST | Sf9 insect cells using baculovirus | 27-end (Y253F) | NM_005157 |
ABL1 (Y253H), Active | A03-12GH | Human | HIS | Sf9 insect cells using baculovirus | 27-end (Y253H) | NM_005157 |
AKT1 (E17K), Active | A16-12G | Human | GST | Sf9 insect cells using baculovirus | Full Length (E17K) | NM_005163 |
AKT1 (E17K), Active | A16-12H | Human | HIS | Sf9 insect cells using baculovirus | Full Length (E17K) | NM_005163 |
AKT1 (E17K), Unactive | A16-16H | Human | HIS | Sf9 insect cells using baculovirus | Full Length | NM_005163 |
AKT1 (E17K), Unactive | A16-16G | Human | GST | Sf9 insect cells using baculovirus | Full Length | NM_005163 |
AKT2 (E17K), Active | A17-12G | Human | GST | Sf9 insect cells using baculovirus | Full Length (E17K) | NM_001626 |
AKT2 (R274H), Active | A17-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (R274H) | NM_001626 |
AKT3 (E17K), Active | A18-12G | Human | GST | Sf9 insect cells using baculovirus | Full Length (E17K) | NM_005465 |
AKT3 (G171R), Active | A18-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (G171R) | NM_005465 |
ALK (C1156Y), Active | A19-12DG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (C1156Y) | NM_004304 |
ALK (F1174L), Active | A19-12EG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (F1174L) | NM_004304 |
ALK (F1174S), Active | A19-12FG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (F1174S) | NM_004304 |
ALK (G1202R), Active | A19-12HG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (G1202R) | NM_004304 |
ALK (G1269A), Active | A19-12JG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (G1269A) | NM_004304 |
ALK (G1269S), Active | A19-12KG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (G1269S) | NM_004304 |
ALK (I1171N D1203N), Active | A19-12PG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (I1171N D1203N) | NM_004304 |
ALK (L1152R), Active | A19-12CG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (L1152R) | NM_004304 |
ALK (L1196M G1202R), Active | A19-12NG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (L1196M G1202R) | NM_004304 |
ALK (L1196M), Active | A19-12GG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (L1196M) | NM_004304 |
ALK (R1275Q), Active | A19-12LG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (R1275Q) | NM_004304 |
ALK (S1206R), Active | A19-12IG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (S1206R) | NM_004304 |
ALK (T1151M), Active | A19-12BG | Human | GST | Sf9 insect cells using baculovirus | 1060-end (T1151M) | NM_004304 |
ALK (T1151_L1152insT), Active | A19-12G | Human | GST | Sf9 insect cells using baculovirus | 1060-end (T1151_L1152insT) | NM_004304 |
ALK2 (G328E), Active | A06-12GG | Human | GST | Sf9 insect cells using baculovirus | 147-end (G328E) | NM_001105 |
ALK2 (G328V), Active | A06-12HG | Human | GST | Sf9 insect cells using baculovirus | 147-end (G328V) | NM_001105 |
ALK2 (G328W), Active | A06-12IG | Human | GST | Sf9 insect cells using baculovirus | 147-end (G328W) | NM_001105 |
ALK2 (G356D), Active | A06-12JG | Human | GST | Sf9 insect cells using baculovirus | 147-end (G356D) | NM_001105 |
ALK2 (PF197_198L), Active | A06-12FG | Human | GST | Sf9 insect cells using baculovirus | 147-end (PF197_198L) | NM_001105 |
ALK2 (Q207D), Active | A06-13CG | Human | GST | Sf9 insect cells using baculovirus | 147-end (Q207D) | NM_001105 |
ALK2 (Q207E), Active | A06-13DG | Human | GST | Sf9 insect cells using baculovirus | 147-end (Q207E) | NM_001105 |
ALK2 (R202I), Active | A06-12EG | Human | GST | Sf9 insect cells using baculovirus | 147-end ((R202I) | NM_001105 |
ALK2 (R206H), Active | A06-12BG | Human | GST | Sf9 insect cells using baculovirus | 147-end (R206H) | NM_001105 |
ALK2 (R206H), Active | A06M-12BG | Mouse | GST | Sf9 insect cells using baculovirus | 147-end (R206H) | P37172-1 |
ALK2 (R258G), Active | A06-12KG | Human | GST | Sf9 insect cells using baculovirus | 147-end (R258G) | NM_001105 |
ALK3 (Q233D), Active | B04-12BG | Human | GST | Sf9 insect cells using baculovirus | 187-end (Q233D) | NM_004329 |
ALK3 (R486Q), Active | B04-12CG | Human | GST | Sf9 insect cells using baculovirus | 187-end (R486Q) | NM_004329 |
ANXA4-PKN1(Aex2Pex13), Active | P70-19G | Human | GST | Sf9 insect cells using baculovirus | 1-3a.a., exons1-2 (ANXA4) - 578a.a.-end, exons13-22 (PKN1) | NM_001153 |
AURORA B (G160L), Active | A31-10BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (G160L) | NM_004217 |
AXL (R499C), Active | A34-12BG | Human | GST | Sf9 insect cells using baculovirus | 473-end (R499C) | NM_021913 |
BCR-RET, Active | R02-19EG | Human | GST | Sf9 insect cells using baculovirus | 1-426 (BCR) - 713-end (RET) | BC066122 |
BRAF (d485-489 P490Y), Active | B08-12IG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (d485-489 P490Y) | NM_004333 |
BRAF (D594G) Protein | B08-12MG | Human | GST | Sf9 insect cells using baculovirus | 381-end (D594G) | NM_004333 |
BRAF (G464V), Active | B08-12JG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (G464V) | NM_004333 |
BRAF (G469A), Active | B08-12FG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (G469A) | NM_004333 |
BRAF (K601E), Active | B08-12BG | Human | GST | Sf9 insect cells using baculovirus | 416-end (K601E) | NM_004333 |
BRAF (L597V), Active | B08-12HG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (L597V) | NM_004333 |
BRAF (R506_K507insVLR), Active | B08-13CG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (R506_K507insVLR) | NM_004333 |
BRAF (T599_V600insT), Active | B08-13BG | Human | GST | Sf9 insect cells using baculovirus | 416-end (T599_V600insT) | NM_004333 |
BRAF (V600A), Active | B08-12EG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (V600A) | NM_004333 |
BRAF (V600D), Active | B08-12CG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (V600D) | NM_004333 |
BRAF (V600E), Active | B08-12G | Human | GST | Sf9 insect cells using baculovirus | 416-end (V600E) | NM_004333 |
BRAF (V600K), Active | B08-12DG | Human | GST | Sf9 insect cells using baculovirus | 381-end or exon 9-18 (V600K) | NM_004333 |
BTK (C481F), Active | B10-12FH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (C481F) | NM_000061 |
BTK (C481R), Active | B10-12GH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (C481R) | NM_000061 |
BTK (C481S), Active | B10-12CH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (C481S) | NM_000061 |
BTK (P190K), Active | B10-12BH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (P190K) | NM_000061 |
BTK (T474I), Active | B10-12HH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (T474I) | NM_000061 |
BTK (Y485F), Active | B10-12IH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (Y485F) | NM_000061 |
c-KIT (A829P), Active | C06-12HG | Human | GST | Sf9 insect cells using baculovirus | 544-end (A829P) | NM_000222 |
c-KIT (d557-558 V654A), Active | K06-12B2G | Human | GST | Sf9 insect cells using baculovirus | 544-end (d557-558 V654A) | NM_000222 |
c-KIT (d557-558 Y823D), Active | K06-12A2G | Human | GST | Sf9 insect cells using baculovirus | 544-end (d557-558 Y823D) | NM_000222 |
c-KIT (d557-558), Active | K06-12WG | Human | GST | Sf9 insect cells using baculovirus | 544-end (d557-558) | NM_000222 |
c-KIT (d560-576 V654A), Active | K06-12C2G | Human | GST | Sf9 insect cells using baculovirus | 544-end (d560-576 V654A) | NM_000222 |
c-KIT (d560-576 Y823D), Active | K06-12YG | Human | GST | Sf9 insect cells using baculovirus | 544-end (d560-576 Y823D) | NM_000222 |
c-KIT (d560-576), Active | K06-12D2G | Human | GST | Sf9 insect cells using baculovirus | 544-end (d560-576) | NM_000222 |
c-KIT (D816E), Active | C06-12IG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D816E) | NM_000222 |
c-KIT (D816F), Active | C06-12JG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D816F) | NM_000222 |
c-KIT (D816H), Active | C06-12KG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D816H) | NM_000222 |
c-KIT (D816I), Active | K06-12XG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D816I) | NM_000222 |
c-KIT (D816V), Active | C06-12LG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D816V) | NM_000222 |
c-KIT (D816Y), Active | C06-12MG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D816Y) | NM_000222 |
c-KIT (D820E), Active | K06-12BG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D820E) | NM_000222 |
c-KIT (D820Y), Active | K06-12CG | Human | GST | Sf9 insect cells using baculovirus | 544-end (D820Y) | NM_000222 |
c-KIT (K642E), Active | C06-12NG | Human | GST | Sf9 insect cells using baculovirus | 544-end (K642E) | NM_000222 |
c-KIT (L576P), Active | K06-12UG | Human | GST | Sf9 insect cells using baculovirus | 544-end (L576P) | NM_000222 |
c-KIT (N822K), Active | K06-12DG | Human | GST | Sf9 insect cells using baculovirus | 544-end (N822K) | NM_000222 |
c-KIT (T670E), Active | K06-12EG | Human | GST | Sf9 insect cells using baculovirus | 544-end (T670E) | NM_000222 |
c-KIT (T670I), Active | C06-12FG | Human | GST | Sf9 insect cells using baculovirus | 544-end (T670I) | BC071593 |
c-KIT (V559A), Active | C06-12OG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V559A) | NM_000222 |
c-KIT (V559D T670I), Active | K06-12QG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V559D T670I) | NM_000222 |
c-KIT (V559D V654A), Active | K06-12RG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V559D V654A) | NM_000222 |
c-KIT (V559D), Active | C06-12PG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V559D) | NM_000222 |
c-KIT (V560G D816V), Active | C06-12TG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V560G D816V) | NM_000222 |
c-KIT (V560G N822K), Active | K06-12VG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V560G N822K) | NM_000222 |
c-KIT (V560G), Active | C06-12SG | Human | GST | Sf9 insect cells using baculovirus | 544-end (V560G) | NM_000222 |
c-KIT (V654A), Active | K06-13G | Human | GST | Sf9 insect cells using baculovirus | 544-end (V654A) | BC071593 |
c-KIT (Y823D), Active | K06-12GG | Human | GST | Sf9 insect cells using baculovirus | 544-end (Y823D) | NM_000222 |
c-MER (A708S), Active | M51-12BG | Human | GST | Sf9 insect cells using baculovirus | 578-872 (A708S) | NM_006343 |
CK1 epsilon (R178C), Active | C66-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (R178C) | NM_001894 |
CK1A1 (E42C), Active | C64-12CG | Human | GST | Sf9 insect cells using baculovirus | Full length (E42C) | NM_001892 |
CK1A1 (I35C), Active | C64-12BG | Human | GST | Sf9 insect cells using baculovirus | Full length (I35C) | NM_001892 |
DDR1 (S496A), Active | D05-12G | Human | GST | Sf9 insect cells using baculovirus | 444-end (S496A) | NM_001954 |
DDR2 (T654M), Active | D06-12G | Human | GST | Sf9 insect cells using baculovirus | 467-end (T654M) | NM_006182 |
DNAJB1-PRKACA, Active | P51-19BG | Human | GST | Sf9 insect cells using baculovirus | 2-70 (DNAJB1) - 16-351 (PRKACA) | NM_006145 |
EGFR (P772_H773insNP) Protein | E10-122D5G | Human | GST | Sf9 insect cells using baculovirus | 669-end | NM_005228 |
EGFR (A763_Y764insFHEA), Active | E10-132BG | Human | GST | Sf9 insect cells using baculovirus | 668-end (A763_Y764insFHEA) | NM_005228 |
EGFR (A763_Y764insFQEA), Active | E10-132UG | Human | GST | Sf9 insect cells using baculovirus | 668-end (A763_Y764insFQEA) | NM_005228 |
EGFR (A767-S768insTLA), Active | E10-132CG | Human | GST | Sf9 insect cells using baculovirus | 668-end (A767-S768insTLA) | NM_005228 |
EGFR (A767_S768insTLA) Protein | E10-13CG | Human | GST | Sf9 insect cells using baculovirus | 695-end (A767_S768insTLA) | NM_005228 |
EGFR (C775S T790M L858R), Active | E10-122D2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (C775S T790M L858R) | NM_005228 |
EGFR (C797A), Active | E10-12RG | Human | GST | Sf9 insect cells using baculovirus | 695-end (C797A) | NM_005228 |
EGFR (C797G L858R), Active | E10-122LG | Human | GST | Sf9 insect cells using baculovirus | 668-end (C797G L858R) | NM_005228 |
EGFR (C797S L858R), Active | E10-122ZG | Human | GST | Sf9 insect cells using baculovirus | 668-end (C797S L858R) | NM_005228 |
EGFR (C797S), Active | E10-122SG | Human | GST | Sf9 insect cells using baculovirus | 668-end (C797S) | NM_005228 |
EGFR (d746), Active | E10-12IG | Human | GST | Sf9 insect cells using baculovirus | 695-end (d746) | NM_005228 |
EGFR (d746-750 C775S T790M L858R), Active | E10-122E2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 C775S T790M L858R) | NM_005228 |
EGFR (d746-750 C797A), Active | E10-122C2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 C797A) | NM_005228 |
EGFR (d746-750 C797G), Active | E10-122NG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 C797G) | NM_005228 |
EGFR (d746-750 C797S), Active | E10-122TG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 C797S) | NM_005228 |
EGFR (D746-750 G724S), Active | E10-122D3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (D746-750 G724S) | NM_005228 |
EGFR (d746-750 L718Q T790M), Active | E10-122E3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 L718Q T790M) | NM_005228 |
EGFR (d746-750 S768I), Active | E10-122B3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 S768I) | NM_005228 |
EGFR (d746-750 T790M C797G) Protein | E10-13TG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M C797G) | NM_005228 |
EGFR (d746-750 T790M C797S L858R), Active | E10-122YG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M C797S L858R) | NM_005228 |
EGFR (d746-750 T790M C797S), Active | E10-122UG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M C797S) | NM_005228 |
EGFR (d746-750 T790M L792F), Active | E10-122G3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M L792F) | NM_005228 |
EGFR (d746-750 T790M L792H), Active | E10-122F3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M L792H) | NM_005228 |
EGFR (d746-750 T790M L798I), Active | E10-122WG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M L978I) | NM_005228 |
EGFR (d746-750 T790M L858R), Active | E10-122XG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M L858R) | NM_005228 |
EGFR (d746-750 T790M) Protein | E10-12KG | Human | GST | Sf9 insect cells using baculovirus | 695-end (d746-750 T790M) | NM_005228 |
EGFR (d746-750 T790M), Active | E10-122KG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750 T790M) | NM_005228 |
EGFR (d746-750), Active | E10-122JG | Human | GST | Sf9 insect cells using baculovirus | 668-end (d746-750) | NM_005228 |
EGFR (d747-749 A750P), Active | E10-12MG | Human | GST | Sf9 insect cells using baculovirus | 695-end (d747-749 A750P) | NM_005228 |
EGFR (d747-749), Active | E10-12LG | Human | GST | Sf9 insect cells using baculovirus | 695-end (d747-749) | NM_005228 |
EGFR (d747-749), Active with mCherry | E10-122MLH | Human | HIS | Sf9 insect cells using baculovirus | 669-end (d747-749) | NM_005228 |
EGFR (d747-752 P753S), Active | E10-12NG | Human | GST | Sf9 insect cells using baculovirus | 695-end (d747-752 P753S) | NM_005228 |
EGFR (d752-759), Active | E10-12OG | Human | GST | Sf9 insect cells using baculovirus | 695-end (d752-759) | NM_005228 |
EGFR (D761Y), Active | E10-12QG | Human | GST | Sf9 insect cells using baculovirus | 695-end (D761Y) | NM_005228 |
EGFR (D761Y), Active | E10-122QG | Human | GST | Sf9 insect cells using baculovirus | 668-end (D761Y) | NM_005228 |
EGFR (D770GY), Active | E10-13KG | Human | GST | Sf9 insect cells using baculovirus | 695-end (D770GY) | NM_005228 |
EGFR (D770GY), Active | E10-132KG | Human | GST | Sf9 insect cells using baculovirus | 668-end (D770GY) | NM_005228 |
EGFR (D770_N771insG), Active | E10-132XG | Human | GST | Sf9 insect cells using baculovirus | 668-end (D770_N771insG) | NM_005228 |
EGFR (D770_N771insGF) Protein | E10-13IG | Human | GST | Sf9 insect cells using baculovirus | 695-end (D770_N771insGF) | NM_005228 |
EGFR (D770_N771insNPG T790M), Active | E10-132TG | Human | GST | Sf9 insect cells using baculovirus | 668-end (D770_N771insNPG T790M) | NM_005228 |
EGFR (D770_N771insNPG), Active | E10-132GG | Human | GST | Sf9 insect cells using baculovirus | 668-end (D770_N771insNPG) | NM_005228 |
EGFR (D770_N771insY), Active | E10-122D4G | Human | GST | Sf9 insect cells using baculovirus | 669-end (D770_N771insY) | NM_005228 |
EGFR (G719C), Active | E10-12FG | Human | GST | Sf9 insect cells using baculovirus | 695-end (G719C) | NM_005228 |
EGFR (G719D), Active | E10-12GG | Human | GST | Sf9 insect cells using baculovirus | 695-end (G719D) | NM_005228 |
EGFR (G719S), Active | E10-12HG | Human | GST | Sf9 insect cells using baculovirus | 695-end (G719S) | NM_005228 |
EGFR (H773-774insAH) Protein | E10-132PG | Human | GST | Sf9 insect cells using baculovirus | 669-end | NM_005228 |
EGFR (H773_V774insAH) Protein | E10-13PG | Human | GST | Sf9 insect cells using baculovirus | 695-end (H773_V774insAH) | NM_005228 |
EGFR (H773_V774insH) Protein | E10-13RG | Human | GST | Sf9 insect cells using baculovirus | 695-end (H773_V774insH) | NM_005228 |
EGFR (H773_V774insNPH) Protein | E10-13OG | Human | GST | Sf9 insect cells using baculovirus | 695-end (H773_V774insNPH) | NM_005228 |
EGFR (H773_V774insPH) Protein | E10-13QG | Human | GST | Sf9 insect cells using baculovirus | 695-end (H773_V774insPH) | NM_005228 |
EGFR (K716A C797S L858R), Active | E10-122S2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (K716A C797S L858R) | NM_005228 |
EGFR (K716A T790M C797S L858R), Active | E10-122P2G | Human | GST tag | Sf9 insect cells using baculovirus | 668-end (K716A T790M C797S L858R) | NM_005228 |
EGFR (K716A), Active | E10-122M2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (K716A) | NM_005228 |
EGFR (K716Q L718Q), Active | E10-122T2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (K716Q L718Q) | NM_005228 |
EGFR (K728A T790M C797S L858R), Active | E10-122Q2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (K728A T790M C797S L858R) | NM_005228 |
EGFR (K728A), Active | E10-122N2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (K728A) | NM_005228 |
EGFR (L718Q C797S L858R), Active | E10-122A3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L718Q C797S L858R) | NM_005228 |
EGFR (L718Q L858R), Active | E10-122C3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L718Q L858R) | NM_005228 |
EGFR (L718Q T790M L858R), Active | E10-122H2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L718Q T790M L858R) | NM_005228 |
EGFR (L718Q), Active | E10-122G2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L718Q) | NM_005228 |
EGFR (L747S), Active | E10-12PG | Human | GST | Sf9 insect cells using baculovirus | 695-end (L747S) | NM_005228 |
EGFR (L747S), Active | E10-122Y2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L747S) | NM_005228 |
EGFR (L792F L858R), Active | E10-122U2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L792F L858R) | NM_005228 |
EGFR (L792F), Active | E10-122I2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L792F) | NM_005228 |
EGFR (L792H C797S L858R), Active | E10-122V2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L792H C797S L858R) | NM_005228 |
EGFR (L792H L858R), Active | E10-122MG | Human | GST | Sf9 insect cells using baculovirus | 668-end (L792H L858R) | NM_005228 |
EGFR (L792H), Active | E10-122J2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (L792H) | NM_005228 |
EGFR (L858R), Active | E10-122BG | Human | GST | Sf9 insect cells using baculovirus | 668-end (L858R) | NM_005228 |
EGFR (L861Q), Active | E10-12CG | Human | GST | Sf9 insect cells using baculovirus | 695-end (L861Q) | NM_005228 |
EGFR (N771-P772insH), Active | E10-132WG | Human | GST tag | Sf9 insect cells using baculovirus | 668-end (N771-P772insH) | NM_005228 |
EGFR (N771_P772insN), Active | E10-132YG | Human | GST | Sf9 insect cells using baculovirus | 668-end (N771_P772insN) | NM_005228 |
EGFR (P772_H773insNPH), Active | E10-13MG | Human | GST | Sf9 insect cells using baculovirus | 695-end (P772_H773insNPH) | NM_005228 |
EGFR (P772_H773insPR), Active | E10-132ZG | Human | GST | Sf9 insect cells using baculovirus | 668-end (P772_H773insPR) | NM_005228 |
EGFR (R999A), Active | E10-122O2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (R999A) | NM_005228 |
EGFR (S768I), Active | E10-122I3G | Human | GST | Sf9 insect cells using baculovirus | 668-end (S768I) | NM_005228 |
EGFR (T790M C797G L858R), Active | E10-122OG | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M C797G L858R) | NM_005228 |
EGFR (T790M C797S L858R R999A), Active | E10-122R2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M C797S L858R R999A) | NM_005228 |
EGFR (T790M C797S L858R), Active | E10-122VG | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M C797S L858R) | NM_005228 |
EGFR (T790M C797S), Active | E10-122B2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M C797S) | NM_005228 |
EGFR (T790M L792F C797S L858R), Active | E10-122W2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M L792F C797S L858R) | NM_005228 |
EGFR (T790M L792F L858R), Active | E10-122K2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M L792F L858R) | NM_005228 |
EGFR (T790M L792H C797S L858R), Active | E10-122X2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M L792H C797S L858R) | NM_005228 |
EGFR (T790M L792H L858R), Active | E10-122L2G | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M L792H L858R) | NM_005228 |
EGFR (T790M L858R), Active | E10-122DG | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M L858R) | NM_005228 |
EGFR (T790M), Active | E10-122EG | Human | GST | Sf9 insect cells using baculovirus | 668-end (T790M) | NM_005228 |
EGFR (V769-D770insGE), Active | E10-132VG | Human | GST tag | Sf9 insect cells using baculovirus | 668-end (V769-D770insGE) | NM_005228 |
EGFR (V769_D770insASV) Protein | E10-13DG | Human | GST | Sf9 insect cells using baculovirus | 695-end (V769_D770insASV) | NM_005228 |
EGFR (V769_D770insGE) Protein | E10-13EG | Human | GST | Sf9 insect cells using baculovirus | 695-end (V769_D770insGE) | NM_005228 |
EGFR (V774_C775insHV) Protein | E10-13SG | Human | GST | Sf9 insect cells using baculovirus | 668-end (V774_C775insHV) | NM_005228 |
EGFR (V948R), Active | E10-122H3H | Human | HIS | Sf9 insect cells using baculovirus | 669-1022 (V948R) | NM_005228 |
EML4-ALK (Eex13Aex20), Active | A19-19G | Human | GST | Sf9 insect cells using baculovirus | EML4 (1-496) - ALK (1058-end) | AB274722 |
EML4-ALK (Eex14Aex20), Active | A19-19GG | Human | GST | Sf9 insect cells using baculovirus | EML4 (1-534) - ALK (1058-end) | NM_019063 |
EML4-ALK (Eex20Aex20), Active | A19-19HG | Human | GST | Sf9 insect cells using baculovirus | EML4 (1-580) - ALK (1058-end) | NM_019063 |
EML4-ALK (Eex6Aex20), Active | A19-19FG | Human | GST | Sf9 insect cells using baculovirus | EML4 (1-222) - ALK (1058-end) | NM_019063 |
ERK1 (K71A) Protein | M29-16H | Human | HIS | E.coli | Full Length | NM_002746 |
ERN1 (R727A R728A), Active | E31-12DG | Human | Sf9 insect cells using baculovirus | 468-end (R727A R728A) | NM_001433 | |
ERN1 (R727A), Active | E31-12BG | Human | GST | Sf9 insect cells using baculovirus | 468-end (R727A) | NM_001433 |
ERN1 (R728A), Active | E31-12CG | Human | GST | Sf9 insect cells using baculovirus | 468-end (R728A) | NM_001433 |
FAM131B-BRAF (Fex2Bex9), Active | B08-19EG | Human | GST | Sf9 insect cells using baculovirus | 1-30 exon 2 (FAB131B) - 381-end or exon 9-18 (BRAF) | BC050543 |
FGFR1 (V561M), Active | F04-13G | Human | GST | Sf9 insect cells using baculovirus | 399-822 (V561M) | NM_023110 |
FGFR1 (W666R), Active | F04-12G | Human | GST | Sf9 insect cells using baculovirus | 399-end (W666R) | NM_023110 |
FGFR1OP-FGFR1, Active | F04-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-173 (FGFR1OP) 429-end (FGFR1) | BC011902 |
FGFR2 (C491A V564I), Active | F05-12PG | Human | GST | Sf9 insect cells using baculovirus | 285-end (C491A V564I) | BC039243 |
FGFR2 (C491A V564L), Active | F05-12QG | Human | GST | Sf9 insect cells using baculovirus | 285-end (C491A V564L) | BC039243 |
FGFR2 (C491A), Active | F05-12HG | Human | GST | Sf9 insect cells using baculovirus | 285-end (C491A) | BC039243 |
FGFR2 (C491F), Active | F05-12IG | Human | GST | Sf9 insect cells using baculovirus | 285-end (C491F) | BC039243 |
FGFR2 (C491S V564L), Active | F05-12MG | Human | GST | Sf9 insect cells using baculovirus | 285-end (C491S V564L) | BC039243 |
FGFR2 (C491S), Active | F05-12JG | Human | GST | Sf9 insect cells using baculovirus | 285-end (C491S) | BC039243 |
FGFR2 (E565A), Active | F05-12KG | Human | GST | Sf9 insect cells using baculovirus | 285-end (E565A) | BC039243 |
FGFR2 (E565G), Active | F05-12CG | Human | GST | Sf9 insect cells using baculovirus | 285-end (E565G) | BC039243 |
FGFR2 (K526E), Active | F05-12BG | Human | GST | Sf9 insect cells using baculovirus | 285-end (K526E) | BC039243 |
FGFR2 (K641R), Active | F05-12DG | Human | GST | Sf9 insect cells using baculovirus | 285-end (K641R) | BC039243 |
FGFR2 (K659N), Active | F05-12EG | Human | GST | Sf9 insect cells using baculovirus | 285-end (K659N) | BC039243 |
FGFR2 (M420I), Active | F05-12SG | Human | GST | Sf9 insect cells using baculovirus | 285-end | BC039243 |
FGFR2 (N549H), Active | F05-12G | Human | GST | Sf9 insect cells using baculovirus | 285-end (N549H) | BC039243 |
FGFR2 (N549K), Active | F05-12NG | Human | GST | Sf9 insect cells using baculovirus | 285-end (N549K) | BC039243 |
FGFR2 (R612T), Active | F05-12GG | Human | GST | Sf9 insect cells using baculovirus | 285-end (R612T) | BC039243 |
FGFR2 (V564F), Active | F05-12FG | Human | GST | Sf9 insect cells using baculovirus | 285-end (V564F) | BC039243 |
FGFR2 (V564I), Active | F05-12RG | Human | GST | Sf9 insect cells using baculovirus | 285-end (V564I) | BC039243 |
FGFR2 (V564L), Active | F05-12LG | Human | GST | Sf9 insect cells using baculovirus | 285-end (V564L) | BC039243 |
FGFR3 (d613-653), Unactive | F06-16HG | Human | GST | Sf9 insect cells using baculovirus | d613-653 | NM_000142 |
FGFR3 (G697C), Active | F06-12FG | Human | GST | Sf9 insect cells using baculovirus | 397-end (G697C) | NM_000142 |
FGFR3 (K650E), Active | F06-12CG | Human | GST | Sf9 insect cells using baculovirus | 397-end (K650E) | NM_000142 |
FGFR3 (K650M), Active | F06-12DG | Human | GST | Sf9 insect cells using baculovirus | 397-end (K650M) | NM_000142 |
FGFR3 (K650Q), Active | F06-12EG | Human | GST | Sf9 insect cells using baculovirus | 397-end (K650Q) | NM_000142 |
FGFR3 (V555M), Active | F06-12GG | Human | GST | Sf9 insect cells using baculovirus | 397-end (V555M) | NM_000142 |
FGFR4 (N535K), Active | F07-12G | Human | GST | Sf9 insect cells using baculovirus | 460-end (N535K) | NM_002011 |
FGFR4 (V550E), Active | F07-12BG | Human | GST | Sf9 insect cells using baculovirus | 460-end (V550E) | NM_002011 |
FGFR4 (V550L), Active | F07-12CG | Human | GST | Sf9 insect cells using baculovirus | 460-end (V550L) | NM_002011 |
FGFR4 (V550M), Active | F07-12DG | Human | GST | Sf9 insect cells using baculovirus | 460-end (V550M) | NM_002011 |
FIP1L1-PDGFR alpha, Active | P12-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-265 (FIP1L1) | AM392758 |
FLT3 (D835Y), Active | F12-12BG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (D835Y) | NM_004119 |
FLT3 (F594_R595insR), Active | F12-12EG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (F594_R595insR) | NM_004119 |
FLT3 (F594_R595insREY), Active | F12-12FG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (F594_R595insREY) | NM_004119 |
FLT3 (F691L D835Y), Active | F12-12KG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (F691L D835Y) | NM_004119 |
FLT3 (N676K), Active | F12-12IG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (N676K) | NM_004119 |
FLT3 (R595_E596insEY), Active | F12-12GG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (R595_E596insEY) | NM_004119 |
FLT3 (Y591-V592insVDFREYEYD D835Y), Active | F12-12JG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (Y591-V592insVDFREYEYD D835Y) | NM_004119 |
FLT3 (Y591-V592insVDFREYEYD F691L), Active | F12-12LG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (Y591-V592insVDFREYEYD F691L) | NM_004119 |
FLT3 (Y591-V592insVDFREYEYD), Active | F12-12HG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (Y591-V592insVDFREYEYD) | NM_004119 |
FLT3-ITD-NPOS, Active | F12-12DG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (FLT3-ITD-NPOS) | NM_004119 |
FLT3-ITD-W51, Active | F12-12CG | Human | GST | Sf9 insect cells using baculovirus | 571-993 (FLT3-ITD-W51) | NM_004119 |
GOPC-ROS1, Active | R14-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-419 (GOPC) - 1881-end (ROS1) | NM_020399 |
GSK3b (C199A), Active | G09-12H | Human | HIS | Sf9 insect cells using baculovirus | Full-length (C199A) | NM_001146156 |
HER2 (d755-759), Active | E27-12BG | Human | GST | Sf9 insect cells using baculovirus | 676-end (d755-759) | NM_004448 |
HER2 (D769H), Active | E27-12GG | Human | GST | Sf9 insect cells using baculovirus | 676-end (D769H) | NM_004448 |
HER2 (D769Y), Active | E27-12HG | Human | GST | Sf9 insect cells using baculovirus | 676-end (D769Y) | NM_004448 |
HER2 (E719G) Protein | E27-12CG | Human | GST | Sf9 insect cells using baculovirus | 676-end (E719G) | NM_004448 |
HER2 (E719K) Protein | E27-12DG | Human | GST | Sf9 insect cells using baculovirus | 676-end (E719K) | NM_004448 |
HER2 (G776VC), Active | E27-13EG | Human | GST | Sf9 insect cells using baculovirus | 676-end (G776VC) | NM_004448 |
HER2 (L755S), Active | E27-12EG | Human | GST | Sf9 insect cells using baculovirus | 676-end (L755S) | NM_004448 |
HER2 (L755W), Active | E27-12FG | Human | GST | Sf9 insect cells using baculovirus | 676-end (L755W) | NM_004448 |
HER2 (L785F), Active | E27-12LG | Human | GST | Sf9 insect cells using baculovirus | 676-end (L785F) | NM_004448 |
HER2 (P780_Y781insGSP), Active | E27-13DG | Human | GST | Sf9 insect cells using baculovirus | 676-end (P780_Y781insGSP) | NM_004448 |
HER2 (R896C), Active | E27-122KG | Human | GST | Sf9 insect cells using baculovirus | 676-end | |
HER2 (T798I), Active | E27-12MG | Human | GST | Sf9 insect cells using baculovirus | 676-end (T798I) | NM_004448 |
HER2 (V777L), Active | E27-12IG | Human | GST | Sf9 insect cells using baculovirus | 676-end (V777L) | NM_004448 |
HER2 (V777_G778insCG), Active | E27-13CG | Human | GST | Sf9 insect cells using baculovirus | 676-end (V777_G778insCG) | NM_004448 |
HER2 (V842I), Active | E27-12JG | Human | GST | Sf9 insect cells using baculovirus | 676-end (V842I) | NM_004448 |
HER2 (V842I), Active | E27-122JG | Human | GST | Sf9 insect cells using baculovirus | 676-end (V842l) | |
HER2 (V956R), Active | E27-12PH | Human | HIS | Sf9 insect cells using baculovirus | 677-1027 (V956R) | NM_004448 |
HER3 (E928G) Protein | E28-32AG | Human | GST | Sf9 insect cells using baculovirus | 684-1020 (E928G) | P21860 |
HER4 (R927Q), Active | E29-12G | Human | GST | Sf9 insect cells using baculovirus | 682-993 (R927Q) | NM_005235 |
InsR (R1201Q), Active | I08-122G | Human | GST | Sf9 insect cells using baculovirus | 980-1382 (R1201Q) | NM_000208 |
JAK1 (R724H), Active | J01-12BG | Human | GST | Sf9 insect cells using baculovirus | 438-end (R724H) | NM_002227 |
KDR (R1032Q) Protein | K01-12G | Human | GST | Sf9 insect cells using baculovirus | 789-end (R1032Q) | NM_002253 |
KIAA1549-BRAF (Kex15Bex9), Active | B08-19CG | Human | GST | Sf9 insect cells using baculovirus | 1320-1643 exon15(KIAA1549) - 381-end or exon9-18 (BRAF) | NM_001164665 |
KIAA1549-BRAF (Kex16Bex9), Active | B08-19BG | Human | GST | Sf9 insect cells using baculovirus | 1320-1749 exon16 (KIAA1549) - 381-end or exon9-18 (BRAF) | NM_001164665 |
KIF5B-ALK (Kex24Aex20), Active | A19-19MG | Human | GST | Sf9 insect cells using baculovirus | 1-921a.a., exons1-24 (KIF5B) - 1058a.a.-end, exons20-29 (ALK) | NM_004521 |
KIF5B-MET (Kex24Mex14), Active | M52-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-921a.a., exons 1-24 (KIF5B) 963 a.a. - end, exons 14-21 (MET) | NM_004521 |
KIF5B-RET (Kex15Rex14), Active | R02-19FG | Human | GST | Sf9 insect cells using baculovirus | 1- 575 a.a., exons1-15 (KIF5B) – 713 a.a. – end, exons 14-21 (RET) | NM_004521 |
KIF5B-RET (V804L), Active | R02-19HG | Human | GST | Sf9 insect cells using baculovirus | 1- 575 a.a., exons1-15 (KIF5B) – 713 a.a. – end, exons 14-21 (RET (V804L)) | NM_004521 |
KIF5B-RET (V804M), Active | R02-19GG | Human | GST | Sf9 insect cells using baculovirus | 1- 575 a.a., exons1-15 (KIF5B) - 713 a.a. – end, exons 14-21 (RET (V804M)) | NM_004521 |
KLC1-ALK (Kex8Aex20), Active | A19-19IG | Human | GST | Sf9 insect cells using baculovirus | 1-420a.a., exons1-8 (KLC1)- 1058a.a.-end, exons20-29 (ALK) | NM_182923 |
LRRK2 (D1994A), Active | L10-12FG | Human | GST | Sf9 insect cells using baculovirus | 968-end (D1994A) | NM_198578 |
LRRK2 (G2019S), Active | L10-12GG | Human | GST | Sf9 insect cells using baculovirus | 968-end (G2019S) | NM_198578 |
LRRK2 (G2385R), Active | L10-12IG | Human | GST | Sf9 insect cells using baculovirus | 968-end (G2385R) | NM_198578 |
LRRK2 (I1371V), Active | L10-12JG | Human | GST | Sf9 insect cells using baculovirus | 968-end (I1371V) | NM_198578 |
LRRK2 (I2020T), Active | L10-12HG | Human | GST | Sf9 insect cells using baculovirus | 968-end (I2020T) | NM_198578 |
LRRK2 (R1441C), Active | L10-12G | Human | GST | Sf9 insect cells using baculovirus | 968-end (R1441C) | NM_198578 |
LRRK2 (R1441G), Active | L10-12BG | Human | GST | Sf9 insect cells using baculovirus | 968-end (R1441G) | NM_198578 |
LRRK2 (R1441H), Active | L10-12CG | Human | GST | Sf9 insect cells using baculovirus | 968-end (R1441H) | NM_198578 |
LRRK2 (Y1699C), Active | L10-12DG | Human | GST | Sf9 insect cells using baculovirus | 968-end (Y1699C) | NM_198578 |
LRRK2 (Y1699G), Active | L10-12EG | Human | GST | Sf9 insect cells using baculovirus | 968-end (Y1699G) | NM_198578 |
MEK1 (K97A), Unactive | M02-16H | Human | HIS | E.coli | Full Length | NM_002755 |
MELK (T460M), Active | M50-12G | Human | GST | Sf9 insect cells using baculovirus | 1-550 (T460M) | NM_014791 |
MET (D1213H), Active | M52-12F2G | Human | GST | Sf9 insect cells using baculovirus | 956-end | NM_000245 |
MET (D1228A), Active | M52-12ZG | Human | GST | Sf9 insect cells using baculovirus | 956-end (D1228A) | NM_000245 |
MET (D1228G), Active | M52-12B2G | Human | GST | Sf9 insect cells using baculovirus | 956-end (D1228G) | NM_000245 |
MET (D1228H), Active | M52-12HG | Human | GST | Sf9 insect cells using baculovirus | 956-end (D1228H) | NM_000245 |
MET (D1228N), Active | M52-12IG | Human | GST | Sf9 insect cells using baculovirus | 956-end (D1228N) | NM_000245 |
MET (D1228V), Active | M52-12C2G | Human | GST | Sf9 insect cells using baculovirus | 956-end (D1228V) | NM_000245 |
MET (D1228Y), Active | M52-12D2G | Human | GST | Sf9 insect cells using baculovirus | 956-end (D1228Y) | NM_000245 |
MET (Del Ex14), Active | M52-12PG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Del Ex14) | NM_000245 |
MET (F1200I), Active | M52-12GG | Human | GST | Sf9 insect cells using baculovirus | 956-end (F1200I) | NM_000245 |
MET (G1090A), Active | M52-12E2G | Human | GST | Sf9 insect cells using baculovirus | 956-end (G1090A) | NM_000245 |
MET (G1163R), Active | M52-12XG | Human | GST | Sf9 insect cells using baculovirus | 956-end (G1163R) | NM_000245 |
MET (H1094L), Active | M52-12VG | Human | GST | Sf9 insect cells using baculovirus | 956-end (H1094L) | NM_000245 |
MET (H1094Y), Active | M52-12WG | Human | GST | Sf9 insect cells using baculovirus | 956-end (H1094Y) | NM_000245 |
MET (K1244R), Active | M52-12QG | Human | GST | Sf9 insect cells using baculovirus | 956-end (K1244R) | NM_000245 |
MET (L1195F), Active | M52-12YG | Human | GST | Sf9 insect cells using baculovirus | 956-end (L1195F) | NM_000245 |
MET (L1195V), Active | M52-12TG | Human | GST | Sf9 insect cells using baculovirus | 956-end (L1195V) | NM_000245 |
MET (M1250I), Active | M52-12SG | Human | GST | Sf9 insect cells using baculovirus | 956-end (M1250I) | NM_000245 |
MET (M1250T), Active | M52-12BG | Human | GST | Sf9 insect cells using baculovirus | 956-end (M1250T) | NM_000245 |
MET (P991S), Active | M52-12CG | Human | GST | Sf9 insect cells using baculovirus | 956-end (P991S) | NM_000245 |
MET (R1227K), Active | M52-12G2G | Human | GST | Sf9 insect cells using baculovirus | 956-end | NM_000245 |
MET (R970C), Active | M52-12OG | Human | GST | Sf9 insect cells using baculovirus | 956-end (R970C) | NM_000245 |
MET (T1173I), Active | M52-12FG | Human | GST | Sf9 insect cells using baculovirus | 956-end (T1173I) | NM_000245 |
MET (T992I), Active | M52-12DG | Human | GST | Sf9 insect cells using baculovirus | 956-end (T992I) | NM_000245 |
MET (V1092I), Active | M52-12EG | Human | GST | Sf9 insect cells using baculovirus | 956-end (V1092I) | NM_000245 |
MET (Y1230A), Active | M52-12JG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Y1230A) | NM_000245 |
MET (Y1230C), Active | M52-12KG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Y1230C) | NM_000245 |
MET (Y1230D), Active | M52-12LG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Y1230D) | NM_000245 |
MET (Y1230H), Active | M52-12MG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Y1230H) | NM_000245 |
MET (Y1230S), Active | M52-12UG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Y1230S) | NM_000245 |
MET (Y1235D), Active | M52-12NG | Human | GST | Sf9 insect cells using baculovirus | 956-end (Y1235D) | NM_000245 |
NPM1-ALK (F1174L), Active | A19-19EG | Human | GST | Sf9 insect cells using baculovirus | 1-117 (NPM1) 1058-end (F1174L) (ALK) | U04946 |
NPM1-ALK, Active | A19-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-117 (NPM1) - 1058-end (ALK) | HSU04946 |
NUAK2 (K81R), Unactive | N20-16G | Human | GST | Sf9 insect cells using baculovirus | Full Length | NM_030952 |
p38 alpha (K53A), Unactive | M39-16H | Human | HIS | E.coli | Full Length | NM_139012 |
p70S6Kb (C150T), Active | R22-12G | Human | GST | Sf9 insect cells using baculovirus | Full length (C150T) | BC000094 |
PAK2 (Y443N), Active | P03-12G | Human | GST | Sf9 insect cells using baculovirus | Full length (Y443N) | NM_002577 |
PDGFR alpha (D842V), Active | P12-12BG | Human | GST | Sf9 insect cells using baculovirus | 550-end (D842V) | NM_006206 |
PDGFR alpha (E675G Y676C), Active | P12-12EG | Human | GST | Sf9 insect cells using baculovirus | 550-end (E675G Y676C) | NM_006206 |
PDGFR alpha (G680R), Active | P12-12DG | Human | GST | Sf9 insect cells using baculovirus | 550-end (G680R) | NM_006206 |
PDGFR alpha (T674I), Active | P12-12CG | Human | GST | Sf9 insect cells using baculovirus | 550-end (T674I) | NM_006206 |
PFKFB3 (S269A), Active | P323-10BG | Human | GST | Sf9 insect cells using baculovirus | Full length (S269A) | NM_004566 |
PI3K (p110 alpha (E542K)/p85 alpha), Active | P27-122DH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (p110 alpha (E542K)/p85 alpha) | NM_006218 |
PI3K (p110 alpha (E545K)/p85 alpha), Active | P27-152H | Human | HIS | Sf9 insect cells using baculovirus | Full Length (p110 alpha (E545K)/p85 alpha) | NM_006218 |
PI3K (p110 alpha (E545K)/p85 alpha), Active | P27-152G | Human | GST | Sf9 insect cells using baculovirus | Full length (p110 alpha (E545K)/p85 alpha) | NM_006218 |
PI3K (p110 alpha (N345K)/p85 alpha), Active | P27-122CH | Human | HIS | Sf9 insect cells using baculovirus | Full Length (p110 alpha (N345K)/p85 alpha) | NM_006218 |
PI3K (p110 alpha(H1047R)/p85 alpha), Active | P27-122EH | Human | HIS | Sf9 insect cells using baculovirus | Full length (p110 alpha(H1047R)/p85 alpha) | NM_006218 |
PI3K (p110 delta (E1021K)/p85 alpha), Active | P30-122H | Human | HIS | Sf9 insect cells using baculovirus | Full-Length (p110 delta (E1021K)/p85 alpha) | p110 delta: NM_005026 |
PKD2 (PRKD2) (G848E), Active | P76-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (G848E) | NM_016457 |
PKD2 (PRKD2) (G870E), Active | P76-12CG | Human | GST | Sf9 insect cells using baculovirus | Full Length (G870E) | NM_016457 |
PLK4 (G95L), Active | P44-12G | Human | GST | Sf9 insect cells using baculovirus | 1-836 (G95L) | NM_014264 |
PRKACA (L206R), Active | P51-19CG | Human | GST | Sf9 insect cells using baculovirus | 1-351 (L206R) | NM_002730 |
PTC1 (CCDC6-RET), Active | R02-19BG | Human | GST | Sf9 insect cells using baculovirus | CCDC6 (1-101)-RET (713-end) | BC036757 |
PTC2 (PRKAR1A-RET), Active | R02-19CG | Human | GST | Sf9 insect cells using baculovirus | PRKAR1A (1-236)-RET (713-end) | NM_002734 |
PTC3 (NCOA4-RET), Active | R02-19DG | Human | GST | Sf9 insect cells using baculovirus | NCOA4 (1-238)-RET (713-end) | BC001562 |
RAF1 (EE), Active | R01-13G | Human | GST | Sf9 insect cells using baculovirus | Y340E-Y341E, 306-end (EE) | NM_002880 |
RAF1 (R391W), Active | R01-12BG | Human | GST | Sf9 insect cells using baculovirus | 307-end (R391W) | NM_002880 |
RET (A883F), Active | R02-12MG | Human | GST | Sf9 insect cells using baculovirus | 658-end (A883F) | NM_020630 |
RET (E762Q), Active | R02-12FG | Human | GST | Sf9 insect cells using baculovirus | 658-end (E762Q) | NM_020630 |
RET (G691S), Active | R02-12DG | Human | GST | Sf9 insect cells using baculovirus | 658-end (G691S) | NM_020630 |
RET (G810R), Active | R02-12VG | Human | GST | Sf9 insect cells using baculovirus | 658-end (G810R) | NM_020630 |
RET (G810S M918T), Active | R02-12WG | Human | GST | Sf9 insect cells using baculovirus | 658-end (G810S M918T) | NM_020630 |
RET (G810V), Active | R02-12QG | Human | GST | Sf9 insect cells using baculovirus | 658-end (G810V) | NM_020630 |
RET (L790F), Active | R02-12LG | Human | GST | Sf9 insect cells using baculovirus | 658-end (L790F) | NM_020630 |
RET (M918T), Active | R02-12JG | Human | GST | Sf9 insect cells using baculovirus | 658-end (M918T) | NM_020630 |
RET (M918T), Active | R02-12JH | Human | HIS | Sf9 insect cells using baculovirus | 658-end (M918T) | NM_020630 |
RET (R749T), Active | R02-12EG | Human | GST | Sf9 insect cells using baculovirus | 658-end (R749T) | NM_020630 |
RET (R813Q), Active | R02-12HG | Human | GST | Sf9 insect cells using baculovirus | 658-end (R813Q) | NM_020630 |
RET (R912P), Active | R02-12PG | Human | GST | Sf9 insect cells using baculovirus | 658-end (R912P) | NM_020630 |
RET (S891A), Active | R02-12IG | Human | GST | Sf9 insect cells using baculovirus | 658-end (S891A) | NM_020630 |
RET (S904A), Active | R02-12OG | Human | GST | Sf9 insect cells using baculovirus | 658-end (S904A) | NM_020630 |
RET (S904A), Active | R02-12OH | Human | HIS | Sf9 insect cells using baculovirus | 658-end (S904A) | NM_020630 |
RET (S904F), Active | R02-12NG | Human | GST | Sf9 insect cells using baculovirus | 658-end (S904F) | NM_020630 |
RET (S904F), Active | R02-12NH | Human | HIS | Sf9 insect cells using baculovirus | 658-end (S904F) | NM_020630 |
RET (V738A), Active | R02-12RG | Human | GST | Sf9 insect cells using baculovirus | 658-end (V738A) | NM_020630 |
RET (V778I), Active | R02-12KG | Human | GST | Sf9 insect cells using baculovirus | 658-end (V778I) | NM_020630 |
RET (V804L), Active | R02-12BG | Human | GST | Sf9 insect cells using baculovirus | 658-end (V804L) | NM_020630 |
RET (V804M G810S), Active | R02-12UG | Human | GST | Sf9 insect cells using baculovirus | 658-end (V804M G810S) | NM_020630 |
RET (V804M), Active | R02-12GG | Human | GST | Sf9 insect cells using baculovirus | 658-end (V804M) | NM_020630 |
RET (Y791F), Active | R02-12CG | Human | GST | Sf9 insect cells using baculovirus | 658-end (Y791F) | NM_020630 |
RET (Y806C), Active | R02-12SG | Human | GST | Sf9 insect cells using baculovirus | 658-end (Y806C) | NM_020630 |
RET (Y806N), Active | R02-12TG | Human | GST | Sf9 insect cells using baculovirus | 658-end (Y806N) | NM_020630 |
RIPK2 (K47A), Unactive | R08-16G | Human | GST | Sf9 insect cells using baculovirus | 1-299 (K47A) | NM_003821 |
RNF130-BRAF (Rex3Bex9), Active | B08-19GG | Human | GST | Sf9 insect cells using baculovirus | 1-231 exon3 (RNF130) - 381-end or exon 9-18 (BRAF) | BC108306 |
ROS1 (F2004C), Active | R14-12FG | Human | GST | Sf9 insect cells using baculovirus | 1881-end (F2004C) | NM_002944 |
ROS1 (F2004I), Active | R14-12GG | Human | GST | Sf9 insect cells using baculovirus | 1881-end (F2004I) | NM_002944 |
ROS1 (G2032R), Active | R14-12BG | Human | GST | Sf9 insect cells using baculovirus | 1881-end (G2032R) | NM_002944 |
ROS1 (G2101A), Active | R14-12EG | Human | GST | Sf9 insect cells using baculovirus | 1881-end (G2101A) | NM_002944 |
ROS1 (G2101C), Active | R14-12DG | Human | GST | Sf9 insect cells using baculovirus | 1881-end (G2101C) | NM_002944 |
ROS1 (L2086F), Active | R14-12CG | Human | GST | Sf9 insect cells using baculovirus | 1881-end (L2086F) | |
RSK2 (I416V), Active | R17-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (I416V) | NM_004586 |
RSK2 (L608F), Active | R17-12CG | Human | GST | Sf9 insect cells using baculovirus | Full Length (L608F) | NM_004586 |
RSK2 (Y483C), Active | R17-12DG | Human | GST | Sf9 insect cells using baculovirus | Full Length (Y483C) | NM_004586 |
SRGAP3-BRAF (Sex12Bex9), Active | B08-19FG | Human | GST | Sf9 insect cells using baculovirus | 1-513 exon12 (SRGAP3) 381-end or exon 9-18 (BRAF) | NM_014850 |
STRN-ALK (Sex3Aex20), Active | A19-19JG | Human | GST | Sf9 insect cells using baculovirus | 1-137 (STRN)-1058-end (ALK) | NM_003162 |
TECR-PKN1(Tex1Pex10), Active | P70-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-5a.a., exons1 (TECR) - 473a.a.-end, exons10-22 (PKN1) | NM_138501 |
TFG-ALK (Tex4Aex20), Active | A19-19KG | Human | GST | Sf9 insect cells using baculovirus | 1-138a.a., exons1-4 (TFG) - 1058a.a.-end, exons20-29 (ALK) | NM_001195478 |
TFG-ALK (Tex5Aex20), Active | A19-19CG | Human | GST | Sf9 insect cells using baculovirus | 1-193 (TFG)-1058-end (ALK) | NM_001195478 |
TFG-MET (Tex5Mex15), Active | M52-19G | Human | GST | Sf9 insect cells using baculovirus | 1-193a.a., exons1-5 (TFG) - 1010a.a.-end, exons15-21 (MET) | NM_001195478 |
TFG-TRKA (TRK-T3), Active | N16-19CG | Human | GST | Sf9 insect cells using baculovirus | 1-193 (TFG)-399-end (TRKA) | NM_001195478 |
TGFBR1 (T204D), Active | T07-13G | Human | GST | Sf9 insect cells using baculovirus | 80-end (T204D) | BC071181 |
TIE2 (A1124V), Active | T04-12GG | Human | GST | Sf9 insect cells using baculovirus | 771-end (A1124V) | NM_000459 |
TIE2 (K855A), Unactive | T04-16BG | Human | GST | Sf9 insect cells using baculovirus | 771-end (K855A) | NM_000459 |
TIE2 (L914F), Active | T04-12IG | Human | GST | Sf9 insect cells using baculovirus | 771-end (L914F) | NM_000459 |
TIE2 (P883A), Active | T04-12CG | Human | GST | Sf9 insect cells using baculovirus | 771-end (P883A) | NM_000459 |
TIE2 (R849W), Active | T04-12BG | Human | GST | Sf9 insect cells using baculovirus | 771-end (R849W) | NM_000459 |
TIE2 (R915C), Active | T04-12JG | Human | GST | Sf9 insect cells using baculovirus | 771-end (R915C) | NM_000459 |
TIE2 (Y1108F), Active | T04-12FG | Human | GST | Sf9 insect cells using baculovirus | 771-end (Y1108F) | NM_000459 |
TIE2 (Y897C), Active | T04-12DG | Human | GST | Sf9 insect cells using baculovirus | 771-end (Y897C) | NM_000459 |
TIE2 (Y897H R915C), Active | T04-12KG | Human | GST | Sf9 insect cells using baculovirus | 771-end (Y897H R915C) | NM_000459 |
TIE2 (Y897H), Active | T04-12HG | Human | GST | Sf9 insect cells using baculovirus | 771-end (Y897H) | NM_000459 |
TIE2 (Y897S), Active | T04-12EG | Human | GST | Sf9 insect cells using baculovirus | 771-end (Y897S) | NM_000459 |
TPM1-ALK, Active | A19-19LG | Human | GST | Sf9 insect cells using baculovirus | TPM1 (1-257)-ALK (1058-end) | NM_001018005 |
TPM3-ALK, Active | A19-19DG | Human | GST | Sf9 insect cells using baculovirus | 1-258 (TPM3) - 1058-end (ALK) | NM_152263 |
TPM3-PDGFR beta, Active | P13-19DG | Human | GST | Sf9 insect cells using baculovirus | 1-258 (TPM3) - 528-end (PDGFRB) | NM_152263 |
TPM3-ROS1, Active | R14-19CG | Human | GST | Sf9 insect cells using baculovirus | 1-258 (TPM3) - 1881-end (ROS1) | NM_152263 |
TPM3-TRKA, Active | N16-19DG | Human | GST | Sf9 insect cells using baculovirus | 1-258 (TPM3) - 399-end (TRKA) | NM_152263 |
TPR-TRKA (TRK-T1), Active | N16-19BG | Human | GST | Sf9 insect cells using baculovirus | 1-191(TPR) - 399-end (TRKA) | NM_003292 |
TRKA (A608D), Active | N16-12DG | Human | GST | Sf9 insect cells using baculovirus | 440-end (A608D) | NM_002529 |
TRKA (F589L), Active | N16-12EG | Human | GST | Sf9 insect cells using baculovirus | 440-end (F589L) | NM_002529 |
TRKA (G595R A608D), Active | N16-12FG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G595R A608D) | NM_002529 |
TRKA (G595R G667A), Active | N16-12JG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G595R G667A) | NM_002529 |
TRKA (G595R G667C), Active | N16-12KG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G595R G667C) | NM_002529 |
TRKA (G595R G667S), Active | N16-12LG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G595R G667S) | NM_002529 |
TRKA (G595R L657M), Active | N16-12GG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G595R L657M) | NM_002529 |
TRKA (G595R), Active | N16-12BG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G595R) | NM_002529 |
TRKA (G667A), Active | N16-12MG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G667A) | NM_002529 |
TRKA (G667C), Active | N16-12CG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G667C) | NM_002529 |
TRKA (G667S), Active | N16-12NG | Human | GST | Sf9 insect cells using baculovirus | 440-end (G667S) | NM_002529 |
TRKA (L657M), Active | N16-12HG | Human | GST | Sf9 insect cells using baculovirus | 440-end (L657M) | NM_002529 |
TRKC (G623E), Active | N18-12BH | Human | HIS | Sf9 insect cells using baculovirus | 507-end (G623E) | NM_001012338 |
TRKC (G623R L686M), Active | N18-12EH | Human | HIS | Sf9 insect cells using baculovirus | 507-end (G623R L686M) | NM_001012338 |
TRKC (G623R), Active | N18-12CH | Human | HIS | Sf9 insect cells using baculovirus | 507-end (G623R) | NM_001012338 |
TRKC (G696A), Active | N18-12FH | Human | HIS | Sf9 insect cells using baculovirus | 454-end (G696A) | NM_001012338 |
TRKC (G696C), Active | N18-12GH | Human | HIS | Sf9 insect cells using baculovirus | 454-end (G696C) | NM_001012338 |
TRKC (L686M), Active | N18-12DH | Human | HIS | Sf9 insect cells using baculovirus | 507-end (L686M) | NM_001012338 |
YES1 (T348I), Active | Y01-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (T348I) | NM_005433 |
ZAP70 (Y319F), Active | Z02-12BG | Human | GST | Sf9 insect cells using baculovirus | Full Length (Y319F) | NM_001079 |
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