Epigenetic enzymes are crucial in maintaining key cellular functions by modifying chromatin structures and controlling gene transcription process. These reversible epigenetic DNA and histone modifications are controlled by important epigenetic enzymes such as methyltransferases and acetyltransferases. Dysregulation of these enzymes have been observed in myriad human diseases such as cancer. In recent years, epigenetic enzymes have emerged as some of the most promising classes of targets for drug discovery projects and development projects.
Scientists at SignalChem have developed a full range of epigenetic enzymes including acetyltransferases, histone deacetylases, methyltransferases and more. Our high-quality recombinant epigenetic enzymes and the assay methods are valuable tools for scientists to conduct research in epigenetics and for the pharmaceutical companies to develop novel therapeutics modulating these biological targets.
Name | Catalog Number | Species | Tag | Expression System | Sequence | Genbank Number |
JMJD6 Protein | J453-30G | Human | GST | Sf9 insect cells using baculovirus | Full Length | BC066654 |
KDM1A Protein | K421-31G | Human | GST | Sf9 insect cells using baculovirus | 172-end | BC048134 |
KDM1B Protein | K421-30BG | Mouse | GST | Sf9 insect cells using baculovirus | Full Length | NM_172262 |
KDM2A Protein | K422-31G | Human | GST | Sf9 insect cells using baculovirus | 1-748 | NM_012308 |
KDM2B Protein | K422-30BG | Human | GST | Sf9 insect cells using baculovirus | Full Length | BC115380 |
KDM4A Protein | K424-31G | Human | GST | Sf9 insect cells using baculovirus | 1-886 | BC002558 |
KDM4B Protein | K424-31BG | Mouse | GST | Sf9 insect cells using baculovirus | 1-725 | NM_172132.2 |
KDM4C Protein | K424-31CG | Human | GST | Sf9 insect cells using baculovirus | 1-460 | BC104861 |
KDM5B Protein | K425-31BG | Mouse | GST | Sf9 insect cells using baculovirus | 1-753 | BC057318 |
KDM5C Protein | K425-31CG | Human | GST | Sf9 insect cells using baculovirus | 1-671 | BC054499 |
PPME1 Protein | P332-30G | Human | GST | Sf9 insect cells using baculovirus | 2-end | BC003046 |
SIRT1 Protein | S35-31EG | Human | GST | E.coli | 193-end | NM_012238 |
SIRT2 Protein | S36-30EG | Human | GST | E.coli | Full Length | NM_030593 |
SIRT3 Protein | S37-30EG | Human | GST | E.coli | Full Length | NM_012239 |
SIRT4 Protein | S38-30EG | Human | GST | E.coli | Full Length | NM_012240 |
SIRT5 Protein | S39-30EG | Human | GST | E.coli | Full Length | NM_012241 |
SIRT6 Protein | S40-30EG | Human | GST | E.coli | Full Length | NM_016539 |
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