Deubiquitinases

Deubiquitinases (DUBs) are a large group of sophisticated protease enzymes that reverse post-translational modification called ubiquitination by cleaving the ubiquitin proteins and ubiquitin-like proteins such as SUMO and NEDD8 from their substrate proteins, hence controlling the fate of myriad cell signaling proteins and their transduction pathways. Deubiquitinases (DUBs) play pivotal roles in the ubiquitin-proteasome cellular pathway. Due to their involvement in multiple key cell signaling processes encompassing diseases such as cancer and neurodegeneration, these enzymes have evolved to be important new therapeutic targets.

In response to the growing market demand, Signalchem has developed an extensive portfolio of deubiquitinase (DUBs) enzymes and proteins alongside our ubiquitin enzymes, UB/UBL modifiers, and substrates. These products provide valuable tools to study their roles in key cellular processes such as protein stability, ubiquitin recycling, and terminating the ubiquitin-dependent signaling. Scientists at Signalchem have developed, optimized and validated an array of assay systems for these DUBs, providing reliable tools for drug discovery and development endeavors.