Recombinant full-length human RAS was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. R05-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R05-30G-20 | 20 ug | $215 | |
R05-30G-50 | 50 ug | $435 | |
R05-30G-BULK | BULK | Contact Us |
Overview:
The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer.
Gene Aliases:
K-ras; N-ras; RASH1; c-bas/has
Genbank Number:
References:
1. Shih, T. Y., et al: Structure and function of p21 ras proteins.
Gene Amplif Anal. 1986;4:53-72.
2. Rodriguez-Viciana, P.: Cancer targets in the Ras pathway.
Cold Spring Harb Symp Quant Biol. 2005;70:461-7.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~47 kDa
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology
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