Recombinant human ALK3 (BMPR1A) (187-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. B04-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
B04-11G-05 | 5 ug | $226 | |
B04-11G-10 | 10 ug | $325 | |
B04-11G-BULK | BULK | Contact Us |
Overview:
BMPR1A (also known as bone morphogenetic protein receptor 1A) is a member of the transmembrane serine/threonine kinase family that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A act as a minor susceptibility gene for PTEN-mutation-negative Cowden syndrome. BMPR1A regulates the PTEN protein levels by decreasing PTEN's association with the degradative pathway (1). BMPR1A trafficking plays a significant role in FOP pathogenesis and is also involved in human T-cell differentiation (2).
Gene Aliases:
ALK3; BMPR1A; 10q23del; ACVRLK3; CD292; SKR5
Genbank Number:
References:
1. Waite, K. A. et.al: BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum. Molec. Genet. 12: 679-684, 2003.
2. Cejalvo, T. et.al: Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development. Immunology 121: 94-104, 2007.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601