Recombinant human ALK7 (135-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A08-35G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A08-35G-20 | 20 ug | $215 | |
A08-35G-50 | 50 ug | $435 | |
A08-35G-BULK | BULK | Contact Us |
Overview:
ALK7 is a type I receptor for the TGFB family of signaling molecules in which type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (1). Alk7 was expressed in all insulin, glucagon, and somatostatin -positive cells of the pancreas (2). GDF3 regulates adipose tissue homeostasis and energy balance under nutrient overload, in part, by signaling through ALK7 and Alk7 showed reduced fat accumulation and partial resistance to diet-induced obesity, similar to Gdf3.
Gene Aliases:
ACVR1C, ACVRLK7
Genbank Number:
References:
1. Bondestam, J. et.al: cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). Cytogenet. Cell Genet. 95: 157-162, 2001.
2. Bertolino, P.et.al: Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function. Proc. Nat. Acad. Sci. 105: 7246-7251, 2008.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~68 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases
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