Recombinant human LIMK1 (285-638) was expressed by baculovirus in Sf9 cells using an N-terminal His tag.
Catalog No. L04-15H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
L04-15H-20 | 20 ug | $215 | |
L04-15H-50 | 50 ug | $435 | |
L04-15H-BULK | BULK | Contact Us |
Overview:
LIMK1 or LIM domain kinase 1 contains a unique combination of 2 N-terminal LIM domain and a C-terminal protein kinase domain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers that can bind to DNA/RNA as well as mediating protein-protein interactions (1). LIMK1 is thought to be a component of an intracellular signaling pathway that may be involved in brain development especially development of nerve cells. LIMK1 may play an important role in areas of the brain that are responsible for processing visual-spatial information (visuospatial constructive cognition). LIMK1 can regulate aspects of the cytoskeleton, the structural framework that helps to determine cell shape, size, and movement (2).
Gene Aliases:
LIMK, KIZ
Genbank Number:
References:
1. Davila, M. et al: LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer. J Biol Chem. 2003;19;278(38):36868-75.
2. Davila, M. et al: Expression of LIM kinase 1 is associated with reversible G1/S phase arrest, chromosomal instability and prostate cancer. Mol Cancer. 2007;8;6:40.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~41 kDa
Luo Shen et al., Taurine chloramine-induced inactivation of cofilin protein through methionine oxidation Free Radical Biology and Medicine July 2014 10.1016/j.freeradbiomed.2014.07.018
BC Nguyen et al., Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture. Phytotherapy Research January 2016 10.1002/ptr.5510
Cao Quan Nguyen Binh et al., Artepillin C and Other Herbal PAK1-blockers: Effects on Hair Cell Proliferation and Related PAK1-dependent Biological Function in Cell Culture Phytotherapy research January 2016 10.1002/ptr.5510
Angiogenesis, Cancer, Cardiovascular Disease, Invasion/Metastasis, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601