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Full-length recombinant human CDC25C was expressed in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C04-20CG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C04-20CG-05 | 5 ug | $226 | |
C04-20CG-10 | 10 ug | $325 | |
C04-20CG-BULK | BULK | Contact Us |
Overview:
CDC25C (also known as cell division cycle 25 homolog C) is a member of the CDC25 phosphatase family. CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. CDC25C activates the partially purified p34 (cdc2)/cyclin B complex and directs the dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis (1). CDC25C also suppresses p53-induced growth arrest. The regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation (2).
Gene Aliases:
CDC25
Genbank Number:
References:
1. Gould, K. L. et.al: Complementation of the mitotic activator, p80(cdc25), by a human protein-tyrosine phosphatase. Science 250: 1573-1576, 1990.
2. Bulavin, D. V. et.al: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411: 102-107, 2001.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~84 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Ser/Thr Kinases
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