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DGKG, Active

Recombinant full-length human DGKG was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D25-10G


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Catalog No. Pack Size Price (USD)
D25-10G-05 5 ug $226
D25-10G-10 10 ug $325
D25-10G-BULK BULK Contact Us  


Overview:

Diacylglycerol kinase gamma (DGKG) is a member of DGK type I subfamily which have EF-hand motifs and two cysteine-rich regions (C1 domain) in the regulatory domain. These enzymes catalyze the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins such as protein kinase C isoforms and RAS guanyl nucleotide-releasing proteins and some transient receptor potential channels. (1) DKAG has been associated with malignancies with its role as tumor suppressor in colorectal cancer. (2) DGKG is also implicated in regulation of cell cycle regulation. (3)


Gene Aliases:

DGKgamma, DAGK3, DAGKgamma


Genbank Number:


References:


1. Sakane, F. et al. (1997) Diacylglycerol kinase J. Biol. Chem. 29, 1139-1143.

2. Kai, M.et al (2017). Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer. Mol. Carcinog. 56, 1743-1752.

3. Matsubara, T. et al. (2006). Nuclear transportation of diacylglycerol kinase γ and its possible function in the nucleus. J. Biol. Chem. 281, 6152-6164.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

116 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway


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