Recombinant full-length human STAT1beta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S52-54G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S52-54G-20 | 20 ug | $215 | |
S52-54G-50 | 50 ug | $435 | |
S52-54G-BULK | BULK | Contact Us |
Overview:
STAT1β is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT1β transcription factor is specific for the IFN pathway and plays a central role in mediating many, if not all, IFN-dependent biological responses (1). Presence of STAT1β leads to an efficient antiviral response when cells were infected with virus suggesting that a STAT-dependent pathway is activated following virus infection by endogenously produced IFN. Virus-induced STAT protein translocation from the cytoplasmic compartment can be detected within 3 h of infection.
Gene Aliases:
ISGF-3; STAT91; DKFZp686B04100
Genbank Number:
References:
1. Improta, T. et al: Susceptibility to virus infection is determined by a Stat-mediated response to the autocrine effect of virus-induced type I interferon. Cytokine. 1997 Jun;9(6):383-93.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~118 kDa
Dietrich J et al., Analysis of lacrimal gland derived mesenchymal stem cell secretome and its impact on epithelial cell survival
Stem cell research July 2019 10.1016/j.scr.2019.101477
Zhanga Xiaolei et al., Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts PNAS January 2012 10.1073/pnas.1121606109
et al., ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3. Bone June 2018
et al., Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent Oncotarget April 2016
Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway
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