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MEK3 (MAP2K3), Unactive

Recombinant full-length human MEK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M04-14G


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Catalog No. Pack Size Price (USD)
M04-14G-20 20 ug $215
M04-14G-50 50 ug $435
M04-14G-BULK BULK Contact Us  


Overview:

Mitogen-acitvated protein kinase kinase 3 (MEK3) is a serine/threonine kinase that is involved in the activation of MAP kinases. MEK3 is a dual-specificity protein kinase that phosphorylates p38 MAP kinase at its activation site Thr-Gly-Tyr and this stimulates the ability of p38 MAPK to phosphorylate protein substrates such as ATF-2 and Elk-1. MEK3 is activated by different forms of cellular stress and inflammatory cytokines. MEK3-null mice are viable and fertile, but their macrophages and dendritic cells are defective in IL-12 production (1). A virulence factor from Yersinia pseudotuberculosis, YopJ, was found to bind directly to MEK3 in vitro and this leads to blockage of its phosphorylation and activation (2).


Gene Aliases:

MAP2K3, MEK3, MAPKK3, PRKMK3, SKK2


Genbank Number:


References:


1. Lu, H.-T. et al: Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (MEK3)-deficient mice. EMBO J. 18: 1845-1857, 1999.

2. Orth, K. et al: Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science 285: 1920-1923, 1999.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

62 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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  MEK6 (MAP2K6), Unactive, M07-14H


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