Recombinant full-length human GSK3alpha was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. G08-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
G08-10G-05 | 5 ug | $226 | |
G08-10G-10 | 10 ug | $325 | |
G08-10G-BULK | BULK | Contact Us |
Overview:
GSK3alpha is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and transcription factors (e.g., JUN) (1). GSK3alpha also plays a role in the WNT and PI3K signaling pathways. Alzheimer disease is associated with increased production and aggregation of amyloid-beta-40 and -42 peptides into plaques. GSK3alpha is required for maximal production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein by presenilin-dependent gamma-secretase cleavage. In vitro, lithium, a GSK3alpha inhibitor, blocks the production of the beta-amyloid peptides by interfering with the gamma-secretase step (2).
Gene Aliases:
GSK3 alpha, DKFZp686D0638
Genbank Number:
References:
1. Ali, A. et al: Glycogen synthase kinase-3 : properties, functions, and regulation. Chem. Rev. 101: 2527-2540, 2001.
2. Phiel, C J. et al: GSK-3-alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423: 435-439, 2003.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~81 kDa
I Pronobis Mira et al., A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient ?catenin destruction Elife September 2015 10.7554/eLife.08022
Zheng Y et al., Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase
scientific reports March 2019 10.1038/s41598-019-40950-7
AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling
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