Recombinant human EGFR (D770_N771insY) (669-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E10-122D4G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E10-122D4G-05 | 5 ug | $226 | |
E10-122D4G-10 | 10 ug | $325 | |
E10-122D4G-BULK | BULK | Contact Us |
Overview:
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.
Genbank Number:
References:
1. Wang K, et al: Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J. Biol. Chem. 279: 53848-53856, 2004.
2. Kobayashi S, et al: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. New Eng. J. Med. 352: 786-792, 2005.
Purity:
Sample purity data. Please refer to the lot-specific datasheet for lot-specific data.
Activity:
Sample activity data. for lot-specific data, please refer to the specific datasheet.
Gene Aliases :
ERBB, mENA, ERBB1, HER1
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. MW 89~100kDa.
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Receptor Tyrosine Kinases
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