Full-length recombinant human SIRT6 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. S40-30EG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S40-30EG-20 | 20 ug | $215 | |
S40-30EG-50 | 50 ug | $435 | |
S40-30EG-BULK | BULK | Contact Us |
Overview:
SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin (1). SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair (2).
Gene Aliases:
SIR2L6, Sirtuin 6
Genbank Number:
References:
1. Michishita, E. et al: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452: 492-496, 2008.
2. Mostoslavsky, R. et al: Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124: 315-329, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66 kDa
Cancer, Cell Cycle, Inflammation
STAY CONNECTED
Fax: 1-604-232-4601