Recombinant full-length human p70S6Kb was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. R22-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R22-10G-05 | 5 ug | $226 | |
R22-10G-10 | 10 ug | $325 | |
R22-10G-BULK | BULK | Contact Us |
Overview:
p70S6Kb is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and is activated by mitogenic stimuli, including growth factors, cytokines, and phorbol esters. p70S6Kb contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. PI3 kinase pathway and mTOR are involved in the activation of p70S6Kb but other pathways can also activate this target protein.
Gene Aliases:
RPS6KB2, STK14B, KLS, P70-beta, P70-beta-1, P70-beta-2, S6K2, p70(S6K)-beta, S6K-beta2, SRK
Genbank Number:
References:
1. Gout, I. et al: Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. J. Biol. Chem. 273: 30061-30064, 1998.
2. Saitoh, M. et al: Cloning and characterization of p70(S6K-beta) defines a novel family of p70 S6 kinases. Biochem. Biophys. Res. Commun. 253: 470-476, 1998.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~85 kDa
Wang Huizhi et al., Convergence of the Mammalian Target of Rapamycin Complex 1- and Glycogen Synthase Kinase 3-βSignaling Pathways Regulates the Innate Inflammatory Response Journal of Immunology May 2011 10.4049/jimmunol.1002513
Xie Hua et al., Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo Molecular Cancer Therapeutics March 2013 10.1158/1535-7163.MCT-12-1241
AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Metabolic Disorder, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601