Recombinant human FLT4 (800-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. F13-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
F13-11G-05 | 5 ug | $226 | |
F13-11G-10 | 10 ug | $325 | |
F13-11G-BULK | BULK | Contact Us |
Overview:
FLT4 or fms-related tyrosine kinase 4 is a tyrosine kinase receptor for vascular endothelial growth factors C and D and highly expressed in lymphangiogenesis and maintenance of the lymphatic endothelium. FLT4 is a marker for lymphatic vessels and some high endothelial venules in human adult tissues and also supported the theory of the venous origin of lymphatic vessels (1). FLT4 plays an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels (2).
Gene Aliases:
VEGFR3; FLT41; LMPH1A; PCL
Genbank Number:
References:
1. Kaipainen, A. et.al: Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Nat. Acad. Sci. 92: 3566-3570, 1995.
2. Dumont, D. J. et..al: Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282: 946-949, 1998.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~85 kDa
DE Heppner et al., The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling. Journal of Biological Chemistry October 2016 10.1074/jbc.M116.749028
Krejci Pavel et al., Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation PLoS One April 2012 10.1371/journal.pone.0035826
AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases
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