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14-3-3 theta Protein

Recombinant full-length human 14-3-3theta was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. Y84-30G


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Catalog No. Pack Size Price (USD)
Y84-30G-50 50 ug $336
Y84-30G-20 20 ug $160
Y84-30G-BULK BULK Contact Us  


Overview:

14-3-3θ (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Through interaction with ASK1, c-jun NH-terminal kinase, and p38 mitogen-activated protein kinase (MAPK), 14-3-3θ plays an important role in controlling apotopsis (1). Induced expression of 14-3-3θ protein has been reported in patients with amyotrophic lateral sclerosis. Additionally, 14-3-3θ has been observed to mediate nucleocytoplasmic shuttling of the N protein (coronavirus nucleocapsid protein) which causes severe acute respiratory syndrome (2).


Gene Aliases:

YWHAQ, 1C5, HS1, 14-3-3


Genbank Number:


References:


1. Lau, J.M. et al: The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007, 27(4):1455-66.

2. The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation.J Virol. 2005 Sep;79(17):11476-86.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~56 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, WNT Signaling


RELATED PRODUCTS


  14-3-3 alpha/beta Protein, Y71-30G

  14-3-3 sigma Protein, Y86-30N

  14-3-3 epsilon Protein, Y75-30N

  14-3-3 epsilon Protein, Y75-30H


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