Recombinant human TRIO (2627-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. T16-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
T16-11G-05 | 5 ug | $226 | |
T16-11G-10 | 10 ug | $325 | |
T16-11G-BULK | BULK | Contact Us |
Overview:
TRIO (Triple functional domain protein) belongs to CAMK Ser/Thr protein kinase family with 5 isoforms produced by alternative splicing. It encodes two Dbl-homology-Pleckstrin-homology (DH-PH) Rho-GEF units with different specificities and a C-terminal serine/threonine kinase domain. It is a Rho-guanine nucleotide exchange factors (GEFs) that catalyzes exchange of GDP for GTP on small Rho-GTPases, such as Rac1, RhoG and RhoA. TRIO was originally identified as a binding partner of the transmembrane tyrosine phosphatase LAR, and they together play a role in coordinating cell-matrix and cytoskeletal rearrangements required for cell migration and cell growth.
Gene Aliases:
(None)
Genbank Number:
References:
1. Debant A, et al. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A. 93:5466-71. 1996.
2. van Rijssel J, et al: The many faces of the guanine-nucleotide exchange factor trio. Cell Adh Migr. 6:482-7. 2012.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~82 kDa
There are no related publications available for this product.
Cancer, ERK/MAPK Pathway, Neurobiology, Ser/Thr Kinases
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