G-alpha 13 (GNA13) is a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. It activates Rho and regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes. Like GNA12, GNA13 proteins are found up-regulated in several human cancers, and the GNA12/GNA13 signaling plays an important role in cancer cell invasion and metastasis.
G13; G alpha-14
1. Cheong, S. C. et al. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol 45, 712 (2009).
2. Kelly, P. A Role for the G12 Family of Heterotrimeric G Proteins in Prostate Cancer Invasion. J Biol Chem 281, 26483 (2006).
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Angiogenesis, Apoptosis/Autophagy, Cancer