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RhoD (Mature form), Active

Recombinant human RhoD (1-207) was expressed in E.coli cells using an N-terminal His tag.
Catalog No. R144-310DH


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Catalog No. Pack Size Price (USD)
R144-310DH-05 5 ug $160
R144-310DH-10 10 ug $226
R144-310DH-BULK BULK Contact Us  


Overview:

RhoD is a member of the Rho gene family that interacts with protein kinases and serves as a target of activated GTPase. Rho binds GTP and plays a critical role in muscle differentiation by regulating the expression of myogenin and MEF2 genes. Furthermore, Rho is involved in endosome dynamics and reorganization of the actin cytoskeleton and plays a role in coordinating membrane transport (1). mDia and ROCK are downstream effectors of Rho mediating Rho action on the actin cytoskeleton; mDia produces actin filaments by nucleation and polymerization and ROCK activate myosin to cross-link them for induction of actomyosin bundles and contractility (2).


Gene Aliases:

Rho; RHOHP1; RHOM


Genbank Number:


References:


1. Gasman, S. et al: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase. Nature Cell Biol. 5: 195-204, 2003.

2. Narumiya, S. et al: Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev. 2009 Jun;28(1-2):65-76.


Specific Activity:

Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~23 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology


RELATED PRODUCTS


  RhoA Mutant (S188A) Protein, R44-32AH


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