Recombinant human ALK1 (144-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A09-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A09-11G-05 | 5 ug | $226 | |
A09-11G-10 | 10 ug | $325 | |
A09-11G-BULK | BULK | Contact Us |
Overview:
ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFβ superfamily (1). ALK1 functions as a TGFβ type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFβ signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported (2).
Gene Aliases:
ACVRL1, ACVRLK1, ALK1, HHT, HHT2, ORW2, SKR3, ALK1, TSR-I
Genbank Number:
References:
1.Ota, T. et al: Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J. Cell Physiol. 2002;193(3):299-318.
2.Tsuzuki, T. et al: ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder. Am. J. Surg. Pathol. 2004; 28(12):1609-14.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~64 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases
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