Recombinant human c-KIT (T670E) (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K06-12EG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
K06-12EG-05 | 5 ug | $226 | |
K06-12EG-10 | 10 ug | $325 | |
K06-12EG-BULK | BULK | Contact Us |
Overview:
c-KIT (T670E) is the human homolog of the proto-oncogene c-kit which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. c-KIT (T670E) is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-KIT (T670E) function in hematopoiesis, melanogenesis, and gametogenesis (1) and mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. c-KIT (T670E) signaling is involved in human skin pigmentation and that this signaling pathway is regulated by sKIT (2). It is also help in regulating primordial germ cell growth.
Gene Aliases:
PBT, SCFR, CD117
Genbank Number:
References:
1. Rothschild, G. et.al: A role for Kit receptor signaling in Leydig cell steroidogenesis. Biol. Reprod. 69: 925-932, 2003.
2. Kasamatsu, S. et.al: Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes. J. Invest. Derm. 128: 1763-1772, 2008.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~73 kDa
Krejci Pavel et al., NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells Journal of Biological Chemistry July 2010 10.1074/jbc.M109.083626
et al., Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation Theranostics December 2022
Cancer, Inflammation, Neurobiology, Receptor Tyrosine Kinases
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