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AURORA A, Active

Recombinant full-length mouse AURORA A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A28-10G


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Catalog No. Pack Size Price (USD)
A28-10G-05 5 ug $226
A28-10G-10 10 ug $325
A28-10G-BULK BULK Contact Us  


Overview:

AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability (1). AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification (2).


Gene Aliases:

IAK; Ark1; Ayk1; STK6; AIRK1; AU019385; AW539821; STK15; AURKA; AIK; AURA; BTAK; AURORA2


Genbank Number:


References:


1. Dutertre, S. et al: On the role of aurora-A in centrosome function. Oncogene. 2002 Sep 9;21(40):6175-83.

2. Katayama, H. et al: The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003 Dec;22(4):451-64.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~71 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  Kinase Assay Buffer I, K01-09

  AURORA A, Active, A28-18G

  WNK1, Active, W02-11G

  AURORA B, Unactive, A31-14G


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