Home   >    Proteins   >   Protein Kinases

PDHK3, Active

Recombinant full-length human PDHK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P59-10G


Shop Online



Catalog No. Pack Size Price (USD)
P59-10G-05 5 ug $226
P59-10G-10 10 ug $325
P59-10G-BULK BULK Contact Us  


Overview:

PDHK3 or Pyruvate Dehydrogenase Kinase 3 is a member of the PDHK family that phosphorylate and inactivate the Pyruvate Dehydrogenase (PDH) (1). PDH is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. HIF-1 induces PDHK3 expression leading to inhibition of mitochondrial respiration (2). Forced expression of PDHK3 in cancer cells results in increased lactic acid accumulation and drugs resistance, whereas knocking down PDHK3 inhibits hypoxia-induced cytoplasmic glycolysis and cell survival.


Gene Aliases:

PDK3


Genbank Number:


References:


1. Gudi, R. et al: Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270: 28989-28994, 1995.

2. Lu, C W. et al: Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem. 2008 Oct 17;283(42):28106-14.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~69 kDa



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Metabolic Disorder, Ser/Thr Kinases


RELATED PRODUCTS


  PDHK1, Active, P57-10G

  PDHK2, Active, P58-10G

  PDHK4, Active, P60-10G

  PDHKtide, P57-58


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox