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BMX, Active

Recombinant full-length human BMX was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. B07-10G


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Catalog No. Pack Size Price (USD)
B07-10G-05 5 ug $226
B07-10G-10 10 ug $325
B07-10G-BULK BULK Contact Us  


Overview:

The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells (1). The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX, is found to induce activation of the Stat signaling pathway (2).


Gene Aliases:

ETK; PSCTK2; PSCTK3


Genbank Number:


References:


1. Tamagnone, L. et al: BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene. 1994 Dec;9(12):3683-8.

2. Saharinen, P. et al: The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. Blood. 1997 Dec 1;90(11):4341-53


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Invasion/Metastasis, JAK/STAT Pathway


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