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CK1 gamma 2, Active

Full length recombinant human CK1 gamma 2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C68-10BG


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Catalog No. Pack Size Price (USD)
C68-10BG-05 5 ug $226
C68-10BG-10 10 ug $325
C68-10BG-BULK BULK Contact Us  


Overview:

CK1γ2 is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. CK1γ2 is a ubiquitously expressed cytoplasmic kinase that can interact and phosphorylate the metastatic tumor antigen 1 short form (MTA1s) co-localizing it in the cytoplasm (1). Phosphorylated MTA1s then sequesters the estrogen receptor-alpha in the cytoplasm of breast cancer cells. CK1γ2 hyperphosphorylates the ceramide transfer protein CERT leading to a decrease in de novo sphingomyelin synthesis. The reduction in synthesis of sphingomyelin is reversed by the expression of CERT mutants that are not hyperphosphorylated (2).


Gene Aliases:

CSNK1G2, CK1G2


Genbank Number:


References:


1. Mishra, S K. et al: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9.

2. Tomishige N. et al: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009 Jan;20(1):348-57.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~73 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


RELATED PRODUCTS


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  CK1 gamma 1, Active, C68-11G


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