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IRAK2, Active

Recombinant full-length human IRAK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I10-10BG


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Catalog No. Pack Size Price (USD)
I10-10BG-05 5 ug $226
I10-10BG-10 10 ug $325
I10-10BG-BULK BULK Contact Us  


Overview:

Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs) (1). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NFB activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M) (2). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation.


Gene Aliases:

IRAK-2, MGC150550


Genbank Number:


References:


1. Muzio, M. et al: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997;278:1612-5.

2. Wesche, H. et al: IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 1999; 274:19403-10.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~103 kDa



There are no related publications available for this product.


RESEARCH AREAS

Inflammation, NfkB Pathway, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  IRAK4, Active, I12-10G

  IRAK3 Protein, I11-34G


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