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SLK, Active

Recombinant full-length human SLK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S11-10G


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Catalog No. Pack Size Price (USD)
S11-10G-05 5 ug $226
S11-10G-10 10 ug $325
S11-10G-BULK BULK Contact Us  


Overview:

SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex (1). Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity (2). CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates.


Gene Aliases:

LOSK, STK2, se20-9, KIAA0204, MGC133067, bA16H23.1


Genbank Number:


References:


1. Burakov A V, et al: LOSK (SLK) protein kinase activity is necessary for microtubule organization in the interphase cell centrosome. Dokl Biol Sci. 2005;403:317-9

2. Chaar Z, et al: v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II. J Biol Chem. 2006 Sep 22;281(38):28193-9.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~180 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


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  FYN C, Unactive, F15-14G

  LKB1(STK11) Protein, L15-30G


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