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PAK1, Active

Recombinant full-length human PAK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P02B-10BG


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Catalog No. Pack Size Price (USD)
P02B-10BG-05 5 ug $226
P02B-10BG-10 10 ug $325
P02B-10BG-BULK BULK Contact Us  


Overview:

PAK1 is a member of the p21-activated kinases (PAKs) which have been implicated in the regulation of cell morphology, motility and transformation. These serine/threonine kinases are activated by and are effectors of small GTPases, CDC42 and RAC. PAK1 belongs to the Group I PAKs which also includes PAK2 and PAK3 (1). PAK1 is a key regulator of the actin cytoskeleton, adhesion and cell motility. Inactive dimeric PAK1 is mainly cytosolic and interaction with the activators Cdc42-GTP and Rac1-GTP stimulates the kinase at the sites of cellular protrusions forming adhesions to the extracellular matrix (2).


Gene Aliases:

PAKalpha, MGC130000, MGC130001


Genbank Number:


References:


1. Jaffer, Z M. et al: p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol. 2002 Jul;34(7):713-7.

2. Parrini, M C. et al: Spatiotemporal regulation of the Pak1 kinase. Biochem Soc Trans. 2005 Aug;33(Pt 4):646-8.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity :

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping :

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~95 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases



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