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BCR Protein

Recombinant human BCR (1-695) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. B01-35G


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Catalog No. Pack Size Price (USD)
B01-35G-20 20 ug $215
B01-35G-50 50 ug $435
B01-35G-BULK BULK Contact Us  


Overview:

BCR (also known as breakpoint cluster region) encodes a phosphoprotein that has serine/threonine kinase activity (1). The human c-ABL oncogene is translocated from chromosome 9 to a region on chromosome 22 (associated with BCR) in chronic myelocytic leukemia. In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced comprising the BCR gene product plus the translocated c-ABL gene from chromosome 9. The BCR-ABL hybrid protein (p210) is formed that displays increased tyrosine kinase activity. A similar DNA rearrangement of the p210 protein is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL) (2).


Gene Aliases:

ALL, CML, PHL, BCR1, D22S11, D22S662, FLJ1645


Genbank Number:


References:


1. Stam, K. et al: Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity. Mol. Cell Biol. 1987; 7(5): 1955-1960.

2. Eridani, S. et al: Molecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia. Cytotechnology; 1: 33-36.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~120 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer


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