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MEK6 (MAP2K6), Unactive

Recombinant full-length human MEK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M07-14G


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Catalog No. Pack Size Price (USD)
M07-14G-20 20 ug $215
M07-14G-50 50 ug $435
M07-14G-BULK BULK Contact Us  


Overview:

Mitogen-acitvated protein kinase kinase 6 (MEK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MAPKs require dual phosphorylation on threonine and tyrosine residues, an activation step carried out by MAPK kinase (1). MEK6 is a dual-specificity protein kinase that activates p38 MAPK. MEK6 phosphorylates p38 MAP kinase at its activation site Thr-Gly-Tyr and this stimulates the ability of p38 MAPK to phosphorylate protein substrates such as ATF-2 and Elk-1. MEK6 is activated by different forms of cellular stress and inflammatory cytokines (2). Activation of MEK6 occurs via phosphorylation of Ser207 and Thr211 on MEK6 by upstream protein kinases.


Gene Aliases:

MAP2K6, MEK6, MAPKK6, PRKMK6, SAPKK3, SKK3


Genbank Number:


References:


1. Dérijard, B. et al: Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 1995; 269(5220):17.

2. Han, J. et al. Characterization of the structure and function of a novel MAP kinase kinase (MEK6). J. Biol. Chem. 1996;271(6):2886-91.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

66 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases


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