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DCAMKL1, Active

Recombinant human DCAMKL1 (266-end) was expressed by baculovirus in Sf9 cells using an N-terminal GST tag.
Catalog No. D14-11G


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Catalog No. Pack Size Price (USD)
D14-11G-05 5 ug $226
D14-11G-10 10 ug $325
D14-11G-BULK BULK Contact Us  


Overview:

DCAMKL1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions) (1). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity (2). DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.


Gene Aliases:

DCLK1; DCDC3A; DCLK; KIAA0369


Genbank Number:


References:


1. Ohmae, S. et.al: Molecular identification and characteri-zation of a family of kinases with homology to Ca(2+) /calmodulin-dependent protein kinases I/IV. J. Biol. Chem. 281: 20427-20439, 2006.

2. Lin, P. T. et,al: DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. J. Neurosci. 20: 9152-9161, 2000.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~80 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases


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