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AURORA C, Active

Recombinant full-length human AURORA C was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A33-10G


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Catalog No. Pack Size Price (USD)
A33-10G-05 5 ug $226
A33-10G-10 10 ug $325
A33-10G-BULK BULK Contact Us  


Overview:

Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2).


Gene Aliases:

AURKC, AIE2, AIK3, AurC, STK13, aurora-C


Genbank Number:


References:


1. Steven, L. et al: Targeting Aurora-2 Kinase in Cancer. Molecular Cancer Therapeutics. 2003;2: 589-595

2. Shingo, T. et al: The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. Genes to Cells. 2004; 9: 383-397


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~61 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases


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  Kinase Dilution Buffer III, K23-09


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