WNK4 or WNK lysine deficient protein kinase 4 is a member of the WNK family of serine-threonine protein kinases which is part of the tight junction complex in kidney cells. WNK4 can regulate the balance between NaCl reabsorption and K(+) secretion. WNK4 negatively regulates the surface expression of SLC12A3, and the loss of this regulation may cause an inherited form of hypertension (1). WNK4 regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. WNK4 is a positive regulator for the WNK-OSR1/SPAK-NCC cascade and is a potential target of antihypertensive drugs (2).
1. Wilson, F. H. et.al: . Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
2. Ohta, A. et.al: Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases