Home   >    Proteins   >   Protein Kinases

WNK4, Active

Recombinant mouse WNK4 (1-441) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. W05-11G


Shop Online



Catalog No. Pack Size Price (USD)
W05-11G-05 5 ug $226
W05-11G-10 10 ug $325
W05-11G-BULK BULK Contact Us  


Overview:

WNK4 or WNK lysine deficient protein kinase 4 is a member of the WNK family of serine-threonine protein kinases which is part of the tight junction complex in kidney cells. WNK4 can regulate the balance between NaCl reabsorption and K(+) secretion. WNK4 negatively regulates the surface expression of SLC12A3, and the loss of this regulation may cause an inherited form of hypertension (1). WNK4 regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. WNK4 is a positive regulator for the WNK-OSR1/SPAK-NCC cascade and is a potential target of antihypertensive drugs (2).


Gene Aliases:

PHA2B; PRKWNK4


Genbank Number:


References:


1. Wilson, F. H. et.al: . Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.

2. Ohta, A. et.al: Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~86 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Ser/Thr Kinases


RELATED PRODUCTS


  Kinase Dilution Buffer III, K23-09

  Kinase Assay Buffer I, K01-09

  ATP Stock Solution, A50-09

  PKA Substrate, C01-58


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox