Overview:

OTUB2 (Otubain 2) is a deubiquinating cysteine proteases that is encoded by the OTUB2 gene and belongs to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin-protein bond to cleave conjugated ubiquitin from proteins, which may play a role in the regulation of protein turnover by inhibiting degradation (1). OTUB-2 mediated deubiquitination of TRAF3 and TRAF6 may be involved in the regulation of virus-triggered type I interferon (IFN)2 induction pathways (2).

Gene Aliases:

C14orf137, OTB2, OTU2

Genbank Number:

NM_023112

References:

1. Balakirev, M.Y. et al: Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep. 4, 5: 517–22, 2013.

2. Li, S. et al: Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6. The Journal of Biological Chemistry 285: 4291-4297, 2010.