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OTUB2, Active

Recombinant human Ubiquitin thioesterase OTUB2 was expressed in E. coli cells using an N-terminal His tag.
Catalog No. O569-380H


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Catalog No. Pack Size Price (USD)
O569-380H-05 5 ug $226
O569-380H-10 10 ug $325
O569-380H-BULK BULK Contact Us  


Overview:

OTUB2 (Otubain 2) is a deubiquinating cysteine proteases that is encoded by the OTUB2 gene and belongs to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin-protein bond to cleave conjugated ubiquitin from proteins, which may play a role in the regulation of protein turnover by inhibiting degradation (1). OTUB-2 mediated deubiquitination of TRAF3 and TRAF6 may be involved in the regulation of virus-triggered type I interferon (IFN)2 induction pathways (2).


Gene Aliases:

C14orf137, OTB2, OTU2


Genbank Number:


References:


1. Balakirev, M.Y. et al: Otubains: a new family of cysteine proteases in the ubiquitin pathway. EMBO Rep. 4, 5: 517–22, 2013.

2. Li, S. et al: Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6. The Journal of Biological Chemistry 285: 4291-4297, 2010.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

30 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


RELATED PRODUCTS


  DUB Reaction Buffer (4X), D01-09

  DUB Substrate I, U06-57


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