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PAD1, Active

Recombinant full-length human PAD1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P312-310G


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Catalog No. Pack Size Price (USD)
P312-310G-05 5 ug $226
P312-310G-10 10 ug $325
P312-310G-BULK BULK Contact Us  


Overview:

PAD1 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD1 is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by the ubiquitin pathway. The overexpression of PAD1 induced a distinctive pattern of multidrug resistance in mammalian cells and moderate resistance to ultraviolet light (1). PAD1 is also responsible for substrate deubiquitination during proteasomal degradation (2).


Gene Aliases:

HPAD10; PADI1; PDI; PDI1


Genbank Number:


References:


1. Spataro, V. et.al: Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. J. Biol. Chem. 272: 30470-30475, 1997.

2. Yao, T. et.al: A cryptic protease couples deubiquitination and degradation by the proteasome. Nature 419: 403-407, 2002.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

95 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Inflammation


RELATED PRODUCTS


  PAD3, Active, P312-310CG

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  PAD4 Inhibitor Screening Kit, P310DG-863

  PAD2 (mouse) Inhibitor Screening Kit, P310BG-863


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