Catalog No. S35-904E
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Sirt1 activator (233% at 10 uM using the BIOMOL Fluor-de-Lys assay)1 It suppressed TNFα release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice2. It inhibited NFkB activation and reduced inflammatory cytokine production in lamina propria mononuclear cells from IBD patients3. It prevented and cured experimental colitis in a mouse model3.
1. VM Nayagam et al. J. Biomol. Screen. 2006 11:959
2. SS Barbieri et al. Circulation 2012 126:1373
3. R Caruso et al. Mucosal Immunol. 2014 May 21 Epub
CAS Registry Number:
Olive green powder
May be dissolved in DMSO (50 mg/ml); or ethanol (20 mg/ml, warm)
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.
There are no related publications available for this product.
Cancer, Cell Cycle, Inflammation