Recombinant human EIF2AK4 (192-1024) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E12-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E12-11G-05 | 5 ug | $226 | |
E12-11G-10 | 10 ug | $325 | |
E12-11G-BULK | BULK | Contact Us |
Overview:
EIF2AK4 or eukaryotic translation initiation factor 2 alpha kinase 4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to downregulate protein synthesis in response to varied cellular stresses (1). The EIF2AK4 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid (2).
Gene Aliases:
GCN2; KIAA1338
Genbank Number:
References:
1. Berlanga, J. J. et.al: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2-alpha kinase. Europ. J. Biochem. 265: 754-762, 1999.
2. Guo, F. et.al: The GCN2 eIF2-alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 5: 103-114, 2007.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~132 kDa
A Jaspart et al., GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration Sci Rep May 2017 10.1038/s41598-017-02276-0
et al., Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration Molecules September 2021
et al., GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress. Molecular pharmacology December 2020
Angiogenesis, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases
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