Full-length recombinant mouse IDO2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. I212-30G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| I212-30G-20 | 20 ug | $215 | |
| I212-30G-50 | 50 ug | $435 | |
| I212-30G-BULK | BULK | Contact Us |
Overview:
IDO2 or indoleamine 2,3-dioxygenase 2 encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway which is highly expressed in kidney, epididymis, and liver (1). IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan and it is expressed in a doxycycline-regulated T-REX cell system and monitored formation of N-formyl-kynurenine (Kyn) (2).
Gene Aliases:
INDOL1
Genbank Number:
References:
1. Ball, H. J.et.al: Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 396: 203-213, 2007. Note: Erratum: Gene 465: 66 only, 2010.
2. Metz, R.et.al: Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 67: 7082-7087, 2007.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~65 kDa
There are no related publications available for this product.
Cell Cycle, Inflammation, Metabolic Disorder
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