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KDM4A Protein

Recombinant human KDM4A (1-886) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K424-31G


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Catalog No. Pack Size Price (USD)
K424-31G-20 20 ug $215
K424-31G-50 50 ug $435
K424-31G-BULK BULK Contact Us  


Overview:

KDM4A or lysine (K)-specific demethylase 4A is a member of the Jumonji domain 2 (JMJD2) family that encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. KDM4A functions in euchromatin to remove histone methylation marks that are associated with active transcription (1). KDM4A also act as a trimethylation-specific demethylase those converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor (2).


Gene Aliases:

JMJD2A; JHDM3A; KIAA0677


Genbank Number:


References:


1. Klose, R. J. et.al: The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442: 312-316, 2006.

2. Whetstine, J. R. et.al: Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125: 467-481, 2006.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~150 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


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