Recombinant full-length human Aurora B was expressed by baculovirus in Sf9 insect cells using an N-terminal His(8) tag.
Catalog No. A31-10H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A31-10H-05 | 5 ug | $226 | |
A31-10H-10 | 10 ug | $325 | |
A31-10H-BULK | BULK | Contact Us |
Overview:
AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers (1). AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92 (2). This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.
Genbank Number:
References:
1. Shannon, K B. et al: Chromosome dynamics: new light on Aurora B kinase function. Curr Biol. 2002 Jul 9;12(13):R458-60. 2. Andrews, P. D. et al: Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6: 253-268, 2004.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity. For specific information on a given lot, see related technical data sheet.
Gene Aliases :
AURKB, AIK2; AIM1; ARK2; AurB; IPL1; AIM-1; STK12
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx. MW ~43-45kDa.
There are no related publications available for this product.
Cancer, Cell Cycle
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