Recombinant full-length human DRAK1 (STK17A) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S33-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S33-10G-05 | 5 ug | $226 | |
S33-10G-10 | 10 ug | $325 | |
S33-10G-BULK | BULK | Contact Us |
Overview:
DRAK1 (STK17A) is a member of the DAP kinase-related apoptosis-inducing protein kinase family. DRAK1 encodes an autophosphorylated nuclear protein with a protein kinase domain which has apoptosis-inducing activity. DRAK1 is capable of autophosphorylation and of phosphorylating myosin light chain as an exogenous substrate. The noncatalytic C terminus of DRAK1 is crucial for full kinase activity (1). DRAK1 is highly expressed in placenta, but also in heart, lung, skeletal muscle, kidney, and pancreas. DRAK1 act as a novel direct target of p53 and a modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells (2).
Gene Aliases:
DRAK1; STK17A
Genbank Number:
References:
1. Sanjo, H. et.al: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J. Biol. Chem. 273: 29066-29071, 1998.
2. Mao P, et.al: Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. J Biol Chem. 2011 Jun 3;286(22):19381-91.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~83kDa
Apoptosis/Autophagy, Metabolic Disorder, Ser/Thr Kinases
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