Recombinant human DLK (1-520) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M20-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M20-11G-05 | 5 ug | $226 | |
M20-11G-10 | 10 ug | $325 | |
M20-11G-BULK | BULK | Contact Us |
Overview:
DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2).
Gene Aliases:
MAP3K12; MUK; ZPK; ZPKP1; MEKK12
Genbank Number:
References:
1. Hirai, S. et al: Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene 12: 641-650, 1996.
2. Ferron, S. R.et.al: Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature 475: 381-385, 2011.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
94 kDa
There are no related publications available for this product.
Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases
STAY CONNECTED
Fax: 1-604-232-4601