Home   >    COVID-19   >   Covid-19 Inhibitors

Bafilomycin A1

ATPase Inhibitor
Catalog No. V115-905

For enquiry on all COVID-19 Inhibitors email us at orders@signalchem.com

Catalog No. Pack Size Price (USD)
V115-905-100 100 ug $55
V115-905-1000 1 mg $160
V115-905-BULK BULK Contact Us  


Bafilomycin A is a macrolide antibiotic and a highly potent V-ATPase inhibitor. It has been well researched for its role as an inhibitor of the vascular proton ATPases and has been administered to demonstrate the requirement of low endosomal pH for viral uncoating. Bafilomycin A has been actively studied for its role against viruses like influenza A and hepatitis C. Scientists are studying clinical implications of using Bafilomycin A1 against the SARS-CoV-2 virus as it has been documented that the Nsp6 and M proteins of SARS-CoV-2 interact with the V1-ATPase subunits.**

A vacuolar H+-ATPase inhibitor, IC50 = 0.6-1.5 nM in bovine chromaffin granules (1). Highly selective for V-ATPase over F-ATPases and P-ATPase. Inhibits autophagy by preventing maturation of autophagic vacuoles via inhibition of fusion between autophagosomes and lysosomes (2). Inhibits bone resorption in various models (3). An extremely useful tool for exploring physiological processes regulated by V-ATPase (4).


1. S Gagliardi et al. Curr. Med. Chem. 1999 6:1197

2. A Yamamoto et al. Cell Struct. Funct. 1998 23:33

3. AV Neutzsky-Wulff et al. BMC Musculoskelet. Disord. 2010 11:109

4. T Yoshimori et al. J. Biol. Chem. 2015 290:8039

CAS Registry Number:


Molecular Formula:



Lyophilized white powder

Molecular Weight:



>98% (HPLC); NMR (conforms)


May be dissolved in DMSO (50 mg/ml)


(-)-Bafilomycin A1

Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.

Molecular Structure:

Product Datasheets

There are no related publications available for this product.



Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox