MEK Inhibitor
Catalog No. M02-901B
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M02-901B-05 | 5 mg | $80 | |
| M02-901B-25 | 25 mg | $300 | |
| M02-901B-BULK | BULK | Contact Us |
Overview:
A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM) (1). Inhibits growth and/or proliferation of a variety of cancer cells (2). Enhances self-renewal of embryonic stem cells (3). In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells (4). In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells (5).
References:
1. SD Barrett et al. Bioorg. Med. Chem. Lett. 2008 18:6501. 2. L Ciuffreda et al. Neoplasia 2009 11:720. 3. Z Ai et al. Stem Cells Int. 2016 2016:1792573. 4. C Li et al. Oncotarget 2016 7:39730. 5. W Li et al. Cell Stem Cell 2009 4:16.
CAS Registry Number:
391210-10-9
Molecular Formula:
C16H14F3IN2O4
Appearance:
White powder
Solubility:
May be dissolved in DMSO (12 mg/ml)
Molecular weight:
482.2
Purity:
≥98% (HPLC); NMR (Conforms)
Storage and Stability:
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
Molecular structure:
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Aliases:
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
There are no related publications available for this product.
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