Recombinant human PDE4B (305-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P92-31BG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
P92-31BG-05 | 5 ug | $259 | |
P92-31BG-10 | 10 ug | $380 | |
P92-31BG-BULK | BULK | Contact Us |
Overview:
PDE4B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and has homology to the 'dunce' gene of Drosophila. The 'dunce' gene is one of several genes critical for normal learning and memory in the fly. Altered activity of PDE4B has been associated with schizophrenia and bipolar affective disorder. DISC1 interacts with the UCR2 domain of PDE4B and elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity (1). PDE4B gene itself does not link to major depressive disorder (MDD) but elevated mRNA levels of PDE4B have been implicated in the pathophysiology of MDD (2).
Gene Aliases:
DPDE4; PDE4B5; PDEIVB; MGC126529; DKFZp686F2182
Genbank Number:
References:
1. Millar J K, et al: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310: 1187-1191, 2005.
2. Numata S, et al: Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2009 Jun 5;150B(4):527-34.
Specific Activity:
Sample Phosphodiesterase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~78 kDa
et al., Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain. European journal of medicinal chemistry October 2018
et al., Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation. European journal of medicinal chemistry March 2018
Cardiovascular Disease, Inflammation, Phosphodiesterases
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