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Tau-410 Protein

Recombinant full-length human tag-free Tau-410 was expressed in E. coli cells.
Catalog No. T06-54N


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Catalog No. Pack Size Price (USD)
T06-54N-50 50 ug $336
T06-54N-20 20 ug $160
T06-54N-BULK BULK Contact Us  


Overview:

Tau-410 or Tau-C is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).


Gene Aliases:

Tau-C, (N2R3), Tau-3, MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549


Genbank Number:


References:


1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in β-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Tau Proteins:

Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316 (Tau Protein Marker; Cat # T08-07N).


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~61 kDa



Product Datasheets



RESEARCH AREAS

Invasion/Metastasis, Neurobiology, p38 Pathway


RELATED PRODUCTS


  GSK3 beta, Unactive, G09-14G

  HSD17B10 Protein, H23-30G

  Tau-441 (151-391) Protein, T08-55FN

  Tau-441 (151-441) Protein, T08-55DN


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